SHH

(redirected from HLP3)

SHH

A gene on chromosome 7q36 that encodes a protein central in early embryonic patterning and the key inductive signal in patterning of the anterior-posterior limb axis, the ventral somites and the ventral neural tube.

Molecular pathology
Defects in SHH or in its signalling pathway cause holoprosencephaly, VACTERL syndrome; mutation upstream of SHH disrupts limb patterning and can result in preaxial polydactyly.
References in classic literature ?
If such a spirit should infest the councils of the Union, the most certain road to the accomplishment of its aim would be to employ the State officers as much as possible, and to attach them to the Union by an accumulation of their emoluments.
Immediately the moon shone out as brightly as if all the troubles of the world, and all the wickedness and the ugliness that infest human life, were past and gone forever.
The night will soon fall; this forest is most wild and lonely; strange noises are often heard therein after sunset; wolves haunt these glades, and Danish warriors infest the country; worse things are talked of; you might chance to hear, as it were, a child cry, and on opening the door to afford it succour, a greet black bull, or a shadowy goblin dog, might rush over the threshold; or, more awful still, if something flapped, as with wings, against the lattice, and then a raven or a white dove flew in and settled on the hearth, such a visitor would be a sure sign of misfortune to the house; therefore, heed my advice, and lift the latchet for nothing.
I fatten a good deal of poultry, but I have to buy grain, and you cannot imagine the army of rats that infest this place.
And the night shall be filled with music, And the cares that infest the day Shall fold their tents like the Arabs, And as silently steal away.
To this the porter replied, as well as he could for trepidation, that he had once before heard of this sea-beast; that it was a cruel demon, with bowels of sulphur and blood of fire, created by evil genii as the means of inflicting misery upon mankind; that the things upon its back were vermin, such as sometimes infest cats and dogs, only a little larger and more savage; and that these vermin had their uses, however evil -- for, through the torture they caused the beast by their nibbling and stingings, it was goaded into that degree of wrath which was requisite to make it roar and commit ill, and so fulfil the vengeful and malicious designs of the wicked genii.
They crowd you-- infest you--swarm about you, and sweat and smell offensively, and look sneaking and mean, and obsequious.
During the year that followed, Clayton was several times attacked by the great apes which now seemed to continually infest the vicinity of the cabin; but as he never again ventured outside without both rifle and revolvers he had little fear of the huge beasts.
They will not sting, but they may infest the victuals," said Miss Allan, and measures were taken at once to divert the ants from their course.
As she swam, her mind, filled with the terrors of the night, conjured recollection of the stories she had heard of the fierce crocodiles which infest certain of the rivers of Borneo.
In the past he had had experience with the rodents and vermin that infest every native village, and, while he was not overscrupulous about such matters, he much preferred the fresh air of the swaying trees to the fetid atmosphere of a hut.
They are so vast and magnificent that the latter seem to be only vermin which infest them.