The advent of this testing approach have allowed registries, such as the National Marrow Donor Program (Minneapolis, Minnesota) and Bone Marrow Donors Worldwide (Leiden, the Netherlands), to accrue the HLA types
of more than 27 million volunteer donors, which provides a rich pool of potential, nonrelated, HLA-matched donors for patients who require lifesaving allogeneic stem cell transplants.
The HLA types
of father and son, shown in Figure 1, revealed the existence of several informative regions; for instance, HLA-A* 03 could be distinguished from A*02 and A*29 and B*44 could be distinguished from B* 13 and B* 51 by length discrepancies (http://www.ebi.ac.uk/imgt/hla/align.html).
In the Johannesburg renal transplantation programme, recipient placement on the waiting list for cadaveric kidney allocation is determined by a composite score comprising length of time on the waiting list, recipient age, and the percentage of panel-reactive antibodies (PRAs, an estimate of the percentage of HLA types
in the general population against which the recipient has antibodies).
The HLA type
of our patient (DRB 15) was similar to the familial polish study (5) Environment agents are probably incriminated in the pathogenesis of sarcoidosis in our patients.
In fact certain minority children such as blacks and Asians have a harder time finding matched donor stem cells in part because there aren't enough minority donors, but also because their HLA types
are generally more diverse.
"There are different HLA types
for each different ethnic group that can have the disorder.
An individual's HLA type
is linked to her ancestry; however, even within a family there is variability in HLA expression.
Because a medical test can determine the HLA type
of a person in just an hour, physicians may someday routinely use HLA type
to decide how aggressively to treat a person with strep A infection.
You can be tested for your genetic type (called HLA type
) by a simple blood test which your doctor can order.
The results show that TPIV200 vaccination was well tolerated by all patients and over 90% developed robust and durable antigen-specific immune responses against FRa without regard for HLA type
, which aligns with the intended mechanism of action of the vaccine.
Blood samples are supplied from potential HLA matched donors for additional tests to confirm their HLA type
and microbiology status prior to transplant.
In addition, customers using Affymetrix Axiom biobank arrays and other genotyping arrays for GWAS and fine mapping will be able to ascertain HLA type
information without the need for further experimentation.