The advent of this testing approach have allowed registries, such as the National Marrow Donor Program (Minneapolis, Minnesota) and Bone Marrow Donors Worldwide (Leiden, the Netherlands), to accrue the HLA types
of more than 27 million volunteer donors, which provides a rich pool of potential, nonrelated, HLA-matched donors for patients who require lifesaving allogeneic stem cell transplants.
6) This technique is a solid-phase assay in which purified HLA molecules (either of a single HLA type
or a combination of types) are attached to beads.
In fact certain minority children such as blacks and Asians have a harder time finding matched donor stem cells in part because there aren't enough minority donors, but also because their HLA types
are generally more diverse.
There are different HLA types
for each different ethnic group that can have the disorder.
An individual's HLA type
is linked to her ancestry; however, even within a family there is variability in HLA expression.
Blood samples are supplied from potential HLA matched donors for additional tests to confirm their HLA type
and microbiology status prior to transplant.
In addition, customers using Affymetrix Axiom biobank arrays and other genotyping arrays for GWAS and fine mapping will be able to ascertain HLA type
information without the need for further experimentation.
Because these "pregnancy" sera often contain antibodies to more than one HLA type
, at least 200 sera are generally used to distinguish all the different types.
The ability of an individual to respond to a particular vaccine is also determined by his or her HLA type
Many of the questions that need to be answered in assignment of an HLA type
for an individual can only be answered by molecular typing methods.
X, A woman in another state whose HLA type
had been determined for unrelated reasons, happened to be HLA compatible.
In transplantation, any cell displaying an HLA type
other than the patient's is "non-self" and is attacked by the immune system as an invader, resulting in the rejection of the tissue bearing those cells.