The degree of HLA mismatch
(spanning 0/6 to 6/6) between the donor and the recipient did not affect either the safety or the efficacy of the therapy.
Thus, minimizing HLA mismatch
between a donor and a recipient is required to ensure successful transplantation [54-56].
These findings were borne out with multivariate analysis for both donors and recipients (e.g., HLA mismatch
, donors who were hypertensive, recipients with diabetes).
Humoral/AMR rejection cases (C4d deposition in the peritubular capillaries) and the cellular rejection biopsies as per the BANFF 2003 criteria were correlated with their HLA mismatch
scoring, pre-transplant PRA levels.
Total nucleated cell dose thresholds depend on the degree of HLA disparity, with a greater TNC dose required for each additional HLA mismatch
In addition, one-way multivariate analysis of variance (MANOVA) to test the hypotheses that there would be one or more mean difference between the factors (HLA antibody, MICA antibody and HLA mismatch
) and graft survival was performed to check for the effect of potential confounders.
Chakkera, "The risk of transplant failure with HLA mismatch
in first adult kidney allografts from deceased donors," Transplantation, vol.
Dohler, "Association of HLA mismatch
with death with a functioning graft after kidney transplantation: A collaborative transplant study report," American Journal of Transplantation, vol.
In our center, the decision of desensitization was mainly based on the laboratory testing results for pretransplant PRA, preformed DSA, HLA mismatch
(MM), and flow complement-dependent cytotoxicity (CDC).
With the "NetMHCIIpan 3.1" Internet-based predication tool, the amino acid sequence of each HLA mismatch
(extracellular domains only, in the FASTA format found on http://www.hla.alleles.org ) was used to predict the binding affinity of all allo-HLApep sequences to the recipients' HLA class II antigens' peptide groove.
Although the number of HLA mismatches
is a potent predictor of transplant outcome, not every HLA mismatch
will have an equal effect on graft failure [6, 7].
Lee et al., "Identification of a permissible HLA mismatch
in hematopoietic stem cell transplantation," Blood, vol.