human leukocyte antigen matching

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human leukocyte antigen matching

Abbreviation: HLA matching
In organ transplantation, determining the compatibility of the antigens present on donor organs with those of the patient who will receive the organ. In general, the more closely the donor and recipient match, the greater the likelihood of a successful graft. Mismatching of organ and recipient increases the chances of organ rejection.
Synonym: histocompatibility locus antigen
See also: matching
References in periodicals archive ?
Vucinic et al., "High-resolution HLA matching in hematopoietic stem cell transplantation: a retrospective collaborative analysis," Blood, vol.
A detailed diagnosis on [beta]-thalassemia and HLA matching was further performed.
(69) Thus, the implications of a commonly performed IVF procedure dramatically expand in scope when coupled with PGD with HLA matching, as the PGD child donor, recipient, and all non-medically participating family members may be affected either psychosocially or physiologically.
In many cases, however, transplant recipients need continual immunosuppression with drugs in order to avoid either acute or chronic rejection, even when HLA matching is available.
It is a promising tool in predicting anti-HLA antibodies with better sensitivity than the former HLA matching methods [148].
(40) In fact, recent studies suggest HLA allele matching, and more specifically epitope matching, results in better long-term graft survival through decreased production of donor-specific antibodies compared with established HLA matching. (41) Moreover, with antigen typing able to identify specificity at the allele level, alleles sharing epitopes to which a recipient has antibodies may be avoided.
"HLA matching was prioritized under the premise it would improve outcomes," Segev said, according to renalbusiness.com.
"Optimization can be individualized, with priorities regarding travel, HLA matching, donor age, transport of donor kidneys, and other parameters left in the hands of the patient and transplant center entering the data," they said.
The HLA matching need not be as precise, for example.
The need to store cord bloods will depend largely on the outcome of research into HLA matching, Dr.
This immunologic evaluation of donor-recipient pairs may be useful in optimizing HLA matching and in guiding donor selection by determining potentially nonimmunogenic HLA mismatches, that is, permissible HLA mismatches.
Also, because HLA matching is so difficult in the marrow context, it is improbable that markets could arise, though we hope to show, market-like incentives could be useful.