A detailed diagnosis on [beta]-thalassemia and HLA matching
was further performed.
53) Creating a child through PGD with HLA matching
nearly ensures that the child-donor and the recipient are well-matched in HLA.
In many cases, however, transplant recipients need continual immunosuppression with drugs in order to avoid either acute or chronic rejection, even when HLA matching
40) In fact, recent studies suggest HLA allele matching, and more specifically epitope matching, results in better long-term graft survival through decreased production of donor-specific antibodies compared with established HLA matching
Few centers provide PGD for any purpose, much less for HLA matching
While HLA matching
improves the outcome of transplantation (utility), the researchers said it decreases the number of nonwhites who undergo transplantation (equity).
The policy addresses HLA matching
, which measures the immune system compatibility between an organ donor and an individual patient.
Improved leukemia-free survival was associated with better HLA matching
, Karnofsky scores of 90 or more, lower white blood cell counts at diagnosis, age younger than 15 years, and first complete remission duration of at least 6 months.
Similarly, beyond the first posttransplant year, they said shipment had no impact on graft survival regardless of the degree of HLA matching
The recipients, 76 blacks and 187 whites, were similar in age, degree of HLA matching
, and incidence of diabetes as the cause of end-stage kidney disease.