human leukocyte antigen matching

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human leukocyte antigen matching

Abbreviation: HLA matching
In organ transplantation, determining the compatibility of the antigens present on donor organs with those of the patient who will receive the organ. In general, the more closely the donor and recipient match, the greater the likelihood of a successful graft. Mismatching of organ and recipient increases the chances of organ rejection.
Synonym: histocompatibility locus antigen
See also: matching
References in periodicals archive ?
A detailed diagnosis on [beta]-thalassemia and HLA matching was further performed.
53) Creating a child through PGD with HLA matching nearly ensures that the child-donor and the recipient are well-matched in HLA.
In many cases, however, transplant recipients need continual immunosuppression with drugs in order to avoid either acute or chronic rejection, even when HLA matching is available.
40) In fact, recent studies suggest HLA allele matching, and more specifically epitope matching, results in better long-term graft survival through decreased production of donor-specific antibodies compared with established HLA matching.
Few centers provide PGD for any purpose, much less for HLA matching.
Forward-looking statements in this release include that We believe that our revenues will be substantial in the coming years and this purchase will improve our margins as well as increase value for our investors; that we intend to develop this technology platform into a functional stem cell production system for the treatment of a variety of indications; that our first indication will be effective and efficient alternative to bone marrow transplantation; that PLX stromal cells are allogenic and will not require HLA matching when used in transplant therapies; that using PluriX[TM] we can produce up to 1,000 patient doses per placenta at a significantly lower cost than current methods.
Pablo Rubinstein of NYBC analyzed the results of their 1,100 transplants and confirmed that better HLA matching of the PCB unit to the patient significantly improves patient outcome.
While HLA matching improves the outcome of transplantation (utility), the researchers said it decreases the number of nonwhites who undergo transplantation (equity).
The policy addresses HLA matching, which measures the immune system compatibility between an organ donor and an individual patient.
Improved leukemia-free survival was associated with better HLA matching, Karnofsky scores of 90 or more, lower white blood cell counts at diagnosis, age younger than 15 years, and first complete remission duration of at least 6 months.
Similarly, beyond the first posttransplant year, they said shipment had no impact on graft survival regardless of the degree of HLA matching.
The recipients, 76 blacks and 187 whites, were similar in age, degree of HLA matching, and incidence of diabetes as the cause of end-stage kidney disease.