human leukocyte antigen matching

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human leukocyte antigen matching

Abbreviation: HLA matching
In organ transplantation, determining the compatibility of the antigens present on donor organs with those of the patient who will receive the organ. In general, the more closely the donor and recipient match, the greater the likelihood of a successful graft. Mismatching of organ and recipient increases the chances of organ rejection.
Synonym: histocompatibility locus antigen
See also: matching
References in periodicals archive ?
This increase in the use of CB is due to favorable results in children, an increase in the availability of CB units with large cell doses, less stringent donor-recipient HLA matching, and rapid identification and acquisition of the unit.
In many cases, however, transplant recipients need continual immunosuppression with drugs in order to avoid either acute or chronic rejection, even when HLA matching is available.
It substitutes for HLA-matched unrelated donors and is less demanding of close HLA matching, hence importantly reducing the barrier for recipients of infrequent HLA types and patients of minority ethnic groups.
But with advancements in immunosuppressants, HLA matching isn't as important as it once was.
Optimization can be individualized, with priorities regarding travel, HLA matching, donor age, transport of donor kidneys, and other parameters left in the hands of the patient and transplant center entering the data," they said.
The HLA matching need not be as precise, for example.
These resulting stromal cells are allogeneic and will not require HLA matching when used in transplant therapies.