Vucinic et al., "High-resolution HLA matching
in hematopoietic stem cell transplantation: a retrospective collaborative analysis," Blood, vol.
A detailed diagnosis on [beta]-thalassemia and HLA matching
was further performed.
(69) Thus, the implications of a commonly performed IVF procedure dramatically expand in scope when coupled with PGD with HLA matching
, as the PGD child donor, recipient, and all non-medically participating family members may be affected either psychosocially or physiologically.
In many cases, however, transplant recipients need continual immunosuppression with drugs in order to avoid either acute or chronic rejection, even when HLA matching
It is a promising tool in predicting anti-HLA antibodies with better sensitivity than the former HLA matching
(40) In fact, recent studies suggest HLA allele matching, and more specifically epitope matching, results in better long-term graft survival through decreased production of donor-specific antibodies compared with established HLA matching
. (41) Moreover, with antigen typing able to identify specificity at the allele level, alleles sharing epitopes to which a recipient has antibodies may be avoided.
was prioritized under the premise it would improve outcomes," Segev said, according to renalbusiness.com.
"Optimization can be individualized, with priorities regarding travel, HLA matching
, donor age, transport of donor kidneys, and other parameters left in the hands of the patient and transplant center entering the data," they said.
The HLA matching
need not be as precise, for example.
The need to store cord bloods will depend largely on the outcome of research into HLA matching
This immunologic evaluation of donor-recipient pairs may be useful in optimizing HLA matching
and in guiding donor selection by determining potentially nonimmunogenic HLA mismatches, that is, permissible HLA mismatches.
Also, because HLA matching
is so difficult in the marrow context, it is improbable that markets could arise, though we hope to show, market-like incentives could be useful.