Human leukocyte antigen (HLA) matching was carried out with his sisters but no HLA match
was found for bone marrow transplant, which is the curative treatment for CGD.
The younger sister was fortunate her brother was a HLA match
who could donate - but he was only 11 months old!
Williams et al., "HLA match
likelihoods for hematopoietic stem-cell grafts in the U.S.
The above mentioned equation for estimating [P.sub.(k)] can be derivate with respect to k donors in order to estimate the number of additional donors required to increase by 1% the expectative of finding a donor with complete or partial HLA match
for a q recipient in the waiting list.
"Once we found an HLA match
, we implanted the embryo into the mother's uterus.
Screening was also undertaken to see if the embryo would be an HLA match
to determine whether it may develop into a suitable stem-cell donor for the sibling with thalassemia.
Both variables were significantly associated with increased numbers of available donors (P = 0.01 for the increase in the fraction of cells that survive storage and thawing and P < 0.0001 for degree of HLA match
(227) Even if a full ban were implemented, parents could elect to reproduce naturally and continuously until one of the naturally conceived children proved to be a strong HLA match
with the ill sibling.
(9) In light of the fact that the patient's donor was haploidentical, a perfect 10 out of 10 HLA match
; it has also been shown that non-myeloablative therapies have shown decreased transplant-related mortality.
: the donor and the recipient have matching HLA types.
If the blood is an HLA match
for the sick child, those cells could potentially be used in the child's treatment.
Umbilical cord blood, the other alternative source of stem cells, is useful for children and for small adults (under 50 kg) and furthermore requires a less stringent HLA match
. Stored umbilical cord blood does not rely on donor presence and current good health.