human leukocyte antigen

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human leukocyte antigen (HLA)

any one of four significant histocompatibility antigens governed by genes of the HLA complex, specific loci on chromosome 6, designated HLA-A, HLA-B, HLA-C, and HLA-D. Each locus has several genetically determined alleles; each of these is associated with certain diseases or conditions; for example, HLA-B27 is usually present in people who have ankylosing spondylitis. The HLA system is used to assess tissue compatibility. White blood cells are used for testing. Perfect tissue compatibility exists only between identical twins. See also histocompatibility gene.

human leukocyte antigen (HLA)


hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.


see homo-.

human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.
References in periodicals archive ?
As the differences in HLA antigens increase, the chances of graft-versus-host disease and the severity of the disease is much greater.
This selective reactivity divided the previously known HLA antigen into to new antigen subgroups or splits of the original "parent" antigen.
A matching system for living donors is essential since about 36% of living donor-recipient pairs will likely be blood-type incompatible, and about 30% of the patients currently on the waitlist for a kidney have HLA antigen desensitization," Montgomery said.
Patients then have to wait for a donor with different HLA antigens.
HLA antigens and haplotypes have been described in connection with different epilepsies since the early 1970s; however the results of such studies have been contradictory (40).
So, when selecting the best recipient for a donor, becomes more important class ii over class I HLA antigens (9).
The presence of anti-HLA antibodies in serum, targeting donor HLA antigens, induces donor cells complement-dependent cytotoxicity.
Sensitization to human leukocyte antigens (HLA) in transplant immunology is the occurrence of alloantibodies in the serum of patients who desire to receive organs, directed towards HLA antigens.
HLA antigens in Turkish race with rheumatic heart disease.