human leukocyte antigen

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human leukocyte antigen (HLA)

any one of four significant histocompatibility antigens governed by genes of the HLA complex, specific loci on chromosome 6, designated HLA-A, HLA-B, HLA-C, and HLA-D. Each locus has several genetically determined alleles; each of these is associated with certain diseases or conditions; for example, HLA-B27 is usually present in people who have ankylosing spondylitis. The HLA system is used to assess tissue compatibility. White blood cells are used for testing. Perfect tissue compatibility exists only between identical twins. See also histocompatibility gene.

human leukocyte antigen (HLA)

The human MAJOR HISTOCOMPATIBILITY COMPLEX.

hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.

human

see homo-.
human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.
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References in periodicals archive ?
The association between the HLA antigens and Takayasu's arteritis in Thai patients.
Impact of Human Leukocyte Antigen Loci and Haplotypes on Intestinal Acute Graft-versus-host Disease after Human Leukocyte Antigen-matched Sibling Peripheral Blood Stem Cell Transplantation
As the differences in HLA antigens increase, the chances of graft-versus-host disease and the severity of the disease is much greater.
Life blood: hidden wealth in the human umbilical cord is offering new hope for patients with leukemia and fatal genetic blood disorders
This selective reactivity divided the previously known HLA antigen into to new antigen subgroups or splits of the original "parent" antigen.
Genotyping Applications for Transplantation and Transfusion Management The Emory Experience
A matching system for living donors is essential since about 36% of living donor-recipient pairs will likely be blood-type incompatible, and about 30% of the patients currently on the waitlist for a kidney have HLA antigen desensitization," Montgomery said.
Living kidney "paired donation" helps find more donors - Hopkins study
Patients then have to wait for a donor with different HLA antigens.
France : Risk of Heart Transplant Rejection Reduced by Desensitising Patient Antibodies
HLA antigens and haplotypes have been described in connection with different epilepsies since the early 1970s; however the results of such studies have been contradictory (40).
Cytokine Polymorphism and HLA Genotyping in Patients with Temporal Lobe Epilepsy Related to Hippocampal Sclerosis
This has enabled the characterization of HLA antigens and alleles.
Targeted Next-Generation Sequencing for Human Leukocyte Antigen Typing in a Clinical Laboratory: Metrics of Relevance and Considerations for Its Successful Implementation
Both class I and class II HLA antigens are thyroid cancer susceptibility factors.
A cardiac patient is sliding into heart failure as opportunities to turn things around are missed: how she found her eventual road to recovery
So, when selecting the best recipient for a donor, becomes more important class ii over class I HLA antigens (9).
Compatibilidad HLA donante-receptor y probabilidades de trasplante renal en una poblacion colombiana
The presence of anti-HLA antibodies in serum, targeting donor HLA antigens, induces donor cells complement-dependent cytotoxicity.
False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor
Sensitization to human leukocyte antigens (HLA) in transplant immunology is the occurrence of alloantibodies in the serum of patients who desire to receive organs, directed towards HLA antigens.
Analysis of platelet eluate for the elucidation of sensitization to HLA in kidney transplant candidate/Analise do eluato de plaqueta para a elucidacao da sensibilizacao ao HLA em um candidato ao transplante de rim
HLA antigens in Turkish race with rheumatic heart disease.
Association of IL1-[alpha] 889CT with clinical outcomes of rheumatic heart disease

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