human leukocyte antigen

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human leukocyte antigen (HLA)

The human MAJOR HISTOCOMPATIBILITY COMPLEX.

hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.
References in periodicals archive ?
Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?
Of these, 28 (87%) showed ab against class I HLA antigens, 16 (50%) against class II, and 12 (38%) tested positive for ab against both class I and class II HLA antigens.
Fearing GVHD, physicians generally refuse to attempt bone marrow transplants that involve more than a single HLA antigen mismatch.
Broxmeyer: By "type" we mean the major histocompatibility loci, what we call HLA antigens. These are human leukocyte antigens.
In low-resolution typing, the patient is typed to the point where the HLA antigen is identified by the allelic group.
In time, antisera were identified that would react with only a subset of cells expressing a previously described specific HLA antigen. This selective reactivity divided the previously known HLA antigen into to new antigen subgroups or splits of the original "parent" antigen.7 Similarly, investigators would identify sera reactive with multiple cells each expressing a previously established, but unique, HLA antigen.
The codogenic HLA antigen determines the reject reaction of organism, and is related to immune response and immunological regulation.
HLA antigen sensitization can cause kidney rejection and make patients incompatible with donors who share their tissue type.
All patients had IgG DSA detected (MFI > 1000) at the time of AMR using the Luminex platform with single HLA antigen beads (One Lambda, Canoga Park, CA, USA).
Direct class I HLA antigen discovery to distinguish virus-infected and cancerous cells.