HLA & disease
HLA & diseaseImmunology The association of HLA haplotypes with specific diseases is determined by calculating
1. Relative risk Patients with a particular HLA antigen X, Number of control subjects without the antigen, divided by Pts without the antigen X, Control subjects with the antigen–but not the disease and.
2. Absolute risk Patients with the HLA antigen divided by the control subjects with the antigen X
Diseases linked to HLA specificities
Addison's disease–B8, DR3, Dw3; ankylosing spondylitis–B27; Behçet's disease–B5; Buerger's disease–B12; celiac disease–gluten-sensitive enteropathy-B8, Dw3; chronic active hepatitis–DR3; de Quervain thyroiditis–Bw35; dermatitis herpetiformis–Dw3; Goodpasture syndrome–DR2; mesangioproliferative glomerulonephritis–DR4; Graves' disease–B8 in whites, Bw35 and Dw12 in Japanese, Bw46 in Chinese; hemochromatosis–A3, B7, B14; IDDM–B8. B15, DRw3, DRw4; IgA nephropathy–B35; juvenile rheumatoid arthritis–B27, DR5, DR8; late onset adrenal hyperplasia with hirsutism–Aw33/B14; myasthenia gravis–A1, A3, B8, Dw3, DR3; psoriasis–Cw6; psoriatic arthritis–B27; Reiter syndrome–B27; rheumatoid arthritis–DR4; Salmonella arthritis–B27; Sjögren syndrome–DR3, B8; lupus erythematosus–DR2, DR3; Takayasu's disease–B52; Yersinia arthritis–B27