KLK8

(redirected from HK8)
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KLK8

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses the degradation of casein, fibrinogen, kininogen, fibronectin and collagen type IV. It cleaves L1CAM in response to increased neural activity, and induces neurite outgrowth and fasciculation of cultured hippocampal neurons.
References in periodicals archive ?
In vivo, up-regulation by androgens occurs for hK2 and hK3 and also for hK5, hK6, hK7, hK8, hK10, and hK11.
The serum changes of hK2 and, especially, hK3 in our studied population were much more dramatic than the changes of the other kallikreins (hK5, hK6, hK7, hK8, hK10, and hK11).
ELISA assays used in the present study Coating/ Dynamic Detection Detection Range, Limit, Kallikrein Antibody ng/L ng/L Reference hK2 mono/mono 2000 6 (8) hK3 mono/mono 2000 1 (9) hK4 mono/poly 20 000 100 (10) hK5 mono/mono 25 000 100 (11) hK6 mono/mono 50 000 100 (12) hK7 mono/mono 20 000 200 (13) hK8 mono/mono 20 000 200 (14) hK10 mono/mono 20 000 50 (15) hK11 mono/mono 50 000 100 (16) hK13 mono/mono 20 000 50 (17) hK14 mono/poly 20 000 100 (18) Mono, monoclonal mouse antibody; poly, polyclonal rabbit antibody.
We found significant correlations between serum concentrations of hK2 and hK3 (positive) or hK10 (negative), between hK4 and hK13 or hK14 (both positive), between hK5 and hK6 (positive), and between hK7 and hK8, hK13, or hK14 (all positive).
Serum hK7 was positively correlated, as before hormone administration, with hK8, hK13, and hK14.
Serum hK7 continued to correlate with hK8, but its correlations with hK13 and hK14, observed both before treatment and with oral estrogens, were lost after 1 year of treatment with cyproterone acetate plus transdermal 17[beta]-estradiol.
No significant effects were observed on urine concentrations of hK5, hK7, hK8, hK11, and hK14.
During the reporting period, the Group's earnings per share increased to HK9.4 cents from HK8.0 cents of the same period of last year.
The baculovirus containing the full-length KLK8 cDNA was amplified for hK8 protein production as described below.
Recombinant hK8 in the dialyzed medium was purified by a three-step column chromatography procedure.
The recombinant hK8 protein was identified and characterized by trypsin digestion and nanoelectrospray mass spectrometry, as described previously in detail for recombinant hK10 (18).
The purified hK8 was used as an immunogen to immunize rabbits and mice.