AIDS dementia complex

(redirected from HIV-Associated Neurocognitive Disorder)
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AIDS de·men·ti·a com·plex (ADC),

a subacute or chronic HIV-1 encephalitis, the most common neurologic complication in the later stages of HIV infection; manifested clinically as a progressive dementia, accompanied by motor abnormalities.

AIDS Dementia Complex

An insidious metabolic encephalopathy affecting up to two-thirds of AIDS patients, which is triggered by HIV and driven by neurotoxins secreted by macrophages and microglia. It may be complicated by infections—e.g., Toxoplasma gondii, CMV, or lymphomas.
Clinical findings Poor concentration, loss of memory, incoordination, dysgraphia, lethargy, apathy.
Note: 30% of asymptomatic HIV-positive subjects have EEG abnormalities or progressive cognitive, motor, or behavioural dysfunction.

AIDS dementia complex

AIDS An insidious–30% of asymptomatic HIV-positive subjects have EEG abnormalities, progressive cognitive, motor, behavioral dysfunction, which affects up to 2⁄3 of AIDS Pts; ADC may be complicated by infections–eg, Toxoplasma gondii, CMV, lymphomas Clinical Inability to concentrate, loss of memory, gait incoordination, dysgraphia, slowing of psychomotor functions and eventually, apathy Pathology Degeneration of subcortical white matter and deep gray matter, white matter vacuolization in the lateral and posterior columns of the spinal cord

AIDS dementia complex

A feature of certain cases of AIDS in which there is so much direct damage to brain cells by HIV that DEMENTIA occurs. The condition occurs in some 20% of people with untreated AIDS in the late stages. The drug ZIDOVUDINE appears to be capable of greatly reducing the likelihood of this effect. Other anti-AIDS drugs may be less useful in preventing ADC.

AIDS dementia complex

A type of brain dysfunction caused by HIV infection that causes difficulty thinking, confusion, and loss of muscular coordination.
Mentioned in: AIDS

AIDS de·men·ti·a com·plex

(ADC) (ādz dĕ-menshē-ă kompleks)
Subacute or chronic HIV-1 encephalitis, the most common neurologic complication in the later stages of HIV infection.
References in periodicals archive ?
Planning deficits in HIV-associated neurocognitive disorders: Component processes, cognitive correlates, and implications for everyday functioning.
Host and viral factors influencing the pathogenesis of HIV-associated neurocognitive disorders. Journal of Neuroimmune Pharmacology, 4(2), 175-189.
Three types off HIV-associated neurocognitive disorders
Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders. Neuropsychology Review, 19(2):152-168.
Predictors of symptomatic HIV-associated neurocognitive disorders in universal health care.
HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors.
Ellis et al., "HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors," Journal of Neuro Virology, vol.
If HIV is diagnosed very early--preferably as soon as possible after inoculation with HIV or at onset of the first flu-like symptoms--and treated with ARVs, the brain has less of an opportunity to act as an independent reservoir for HIV-infected cells and therefore to develop HIV-associated neurocognitive disorders. (9), (10) Table 1 outlines steps psychiatrists can take to help prevent HIV transmission.
The second section focuses on these activities in specific populations, including individuals with dementia and mild cognitive impairment, vascular dementia, traumatic brain injury, sports injuries and concussion, multiple sclerosis, HIV-associated neurocognitive disorders, depression, and schizophrenia, as well as normal aging processes.
The grant will help fund research into the therapeutic potential of interferon (IFN)-beta for HIV-associated neurocognitive disorders in opioid users.
There have been a myriad complex acronyms for neurocognitive dysfunction disorders over the years, but these all generally now come under the umbrella of HAND, HIV-associated neurocognitive disorders. These range from asymptomatic neurocognitive impairment (ANI) to HIV-associated mild neurocognitive disorder (MND) to HIV-associated dementia (HAD).
This spectrum of disease is known collectively as HIV-associated neurocognitive disorders (HAND).[1]