Using universal polymerase chain reaction HIV-1, HIV-2
, and SIV primers, we detected 1 (1.4%) HIV-1 sequence.
Persons infected with HIV-2
typically have a slower development of immunodeficiency, and are less infectious in the early stages of infection.
Grossman, Sousa, and their colleagues recently showed that if people infected with HIV-1 and HIV-2
experience similar amounts of immune activation, their blood concentrations of CD4 T cells are reduced by about the same amount, though the HIV-2
carriers have much lower viral loads.
infections are predominantly found in Africa.
In November 1994, a plasma donation was destroyed after the serum tested positive by combination HIV-1/HIV-2 EIA and RUO HIV-2
Serum samples repeatedly reactive by HIV-1 EIA were tested with a whole-virus lysate HIV-2
EIA (Genetic Systems, Seattle, Washington) that was recently licensed by the Food and Drug Administration (FDA).
Her second husband and the four children who were tested had no serologic evidence of HIV-1 or HIV-2
Of the 618 women initially not infected with either HIV-1 or HIV-2
, 61 later tested positive for HIV-1, Kanki and her colleagues report in the June 16 Science.
In 1988, the researchers injected a single baboon with a strain of HIV-2
isolated from a West African patient.
Researchers first demonstrated the existence of HIV-2
in a 1985 study conducted in the West African country of Senegal.
case of AIDS caused by the virus called HIV-2
. Although HIV-2
infection is frequently found in parts of West Africa, HIV-1 has been the cause of AIDS in the United States.
Two previously unknown relatives of HIV have also been discovered (HIV-2
and STLV-III), leaving researchers awash in an alphabet soup of distinct but related viruses--including some that infect humans, some that are restricted to monkeys, some that cause disease and some that apparently do not.