AIDS dementia complex

(redirected from HIV dementia)

AIDS de·men·ti·a com·plex (ADC),

a subacute or chronic HIV-1 encephalitis, the most common neurologic complication in the later stages of HIV infection; manifested clinically as a progressive dementia, accompanied by motor abnormalities.

AIDS Dementia Complex

An insidious metabolic encephalopathy affecting up to two-thirds of AIDS patients, which is triggered by HIV and driven by neurotoxins secreted by macrophages and microglia. It may be complicated by infections—e.g., Toxoplasma gondii, CMV, or lymphomas.
Clinical findings Poor concentration, loss of memory, incoordination, dysgraphia, lethargy, apathy.
Note: 30% of asymptomatic HIV-positive subjects have EEG abnormalities or progressive cognitive, motor, or behavioural dysfunction.

AIDS dementia complex

AIDS An insidious–30% of asymptomatic HIV-positive subjects have EEG abnormalities, progressive cognitive, motor, behavioral dysfunction, which affects up to 2⁄3 of AIDS Pts; ADC may be complicated by infections–eg, Toxoplasma gondii, CMV, lymphomas Clinical Inability to concentrate, loss of memory, gait incoordination, dysgraphia, slowing of psychomotor functions and eventually, apathy Pathology Degeneration of subcortical white matter and deep gray matter, white matter vacuolization in the lateral and posterior columns of the spinal cord

AIDS dementia complex

A feature of certain cases of AIDS in which there is so much direct damage to brain cells by HIV that DEMENTIA occurs. The condition occurs in some 20% of people with untreated AIDS in the late stages. The drug ZIDOVUDINE appears to be capable of greatly reducing the likelihood of this effect. Other anti-AIDS drugs may be less useful in preventing ADC.

AIDS dementia complex

A type of brain dysfunction caused by HIV infection that causes difficulty thinking, confusion, and loss of muscular coordination.
Mentioned in: AIDS

AIDS de·men·ti·a com·plex

(ADC) (ādz dĕ-menshē-ă kompleks)
Subacute or chronic HIV-1 encephalitis, the most common neurologic complication in the later stages of HIV infection.
References in periodicals archive ?
The neurocognitive assessment was performed using the following instruments: Grooved Pegboard Test, Color Trails Test (CTT) parts 1 and 2, Finger Tapping Test, Montreal Cognitive Assessment, and the International HIV Dementia Scale (IHDS).
During early stages of immune dysfunction, manifestations like Bell's palsy and GBS are common, but during late stages more severe disorders like cryptococcal meningitis, TB meningitis, CMV encephalitis, HIV dementia and the polyradiculopathy appears.
Oxidative stress and therapeutic approaches in HIV dementia," Antioxidants and Redox Signaling, vol.
cleaning, cooking, shopping, money management, work tasks or driving) IHDS = International HIV Dementia Scale; MMSE = mini mental state examination; HDS = HIV dementia scale; MoCA = Montreal Cognitive Assessment; CNS = central nervous system; OI = opportunistic infection; HIV-D = HIV-dementia; MND = mild neurocognitive disorder; NP = neuropsychological; HCWs = healthcare workers; CT = computed tomography.
To assess HAD, the Modified HIV Dementia Scale (Davis, Skolasky, Seines, Burgess, & McArthur, 2002) and the International HIV Dementia Scale (Sacktor et al.
Because the Mini-Mental Status Examination may not be sensitive for patients with NPH who have subcortical dementia, (2) the HIV Dementia Scale or the Montreal Cognitive Assessment may be more sensitive for this population.
The clinical syndromes identified include sensory neuropathy, myelopathy, HIV dementia, and cognitive/motor disorder.
Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia.
We started with the opposite hypothesis - that heroin was going to destroy neurons in the brain and lead to HIV dementia.
Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV dementia has dropped by 50% [4].
A proton magnetic resonance spectroscopy comparison of 61 people with HIV dementia, 39 HIV-infected people without neurologic symptoms, and 37 HIV-negative controls found that HIV infection and aging had additive effects on brain metabolites associated with inflammation that could heighten the risk of cognitive slippage.
Funded by the National Institute of Mental Health, the latest research project aims at finding out the first treatment for the neurological effects of HIV, known collectively as neuroAIDS or HIV dementia.