heparin-induced thrombocytopenia(redirected from HIT syndrome)
heparin-induced thrombocytopeniaAcquired thrombocytopenia affecting some heparin-treated Pts–HTPs, defined as a ↓ platelet count during or shortly after heparin exposure; HIT is a markedly prothrombotic disorder seen in Pts who are at a high baseline risk for venous thrombosis DiffDx Antiphospholipid antibody syndrome, DIC, Trousseau syndrome–migratory thrombophlebitis & malignancy, TTP/HUS, thrombocytopenia and 'showers' of microthrombi Clinical HIT occurs 6-10 days after heparin exposure Diagnosis Aggregation studies using platelets from Pts known to be sensitive to antibody; quantification of serotonin release from platelets radiolabeled with serotonin in assay using Pt serum.
Thrombocytopenia caused by an immune reaction to heparin. It may lead to widespread or potentially life-threatening blood clotting rather than bleeding. See: white-clot syndrome
CAUTION!Patients whose platelet counts drop significantly during exposure to heparin should discontinue the drug immediately.
See also: thrombocytopenia