HIF1A


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HIF1A

A gene on chromosome 14q23.2 that encodes hypoxia-inducible factor-1 (HIF1), a transcription factor produced by mammalian cells cultured under reduced oxygen tension, which plays an essential role in homeostatic responses to hypoxia, activating the transcription of over 40 genes including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.

HIF1 plays an essential role in embryonic vascularisation, tumour angiogenesis and pathophysiology of ischaemic disease. HIF1 is a heterodimer composed of an alpha subunit (encoded by HIF1A) and a beta subunit (aryl hydrocarbon receptor nuclear translocator) encoded by ARNT.

Molecular pathology
Overexpression of a natural antisense transcript (aHIF) of HIF1A is associated with nonpapillary renal carcinomas.
References in periodicals archive ?
Resulta interesante que el gen ARD1 (ARDIA, N-[alfa]-acetiltransferasa 10; locus Xq28) codifica para una acetiltransferasa de proteinas; la enzima media la interaccion con la proteina codificada por el gen HIF1A (Factor 1 inducido por hipoxia) regulando su estabilidad, lo cual a su vez aumenta la expresion deARNm del gen VEGF (Factor de crecimiento del endotelio vascular), responsable de la angiogenesis en condiciones de hipoxia (Fig.
Candidate target genes of hsa-miR-424-5p and hsa-miR-377 Gene name Main pathway Target Accession gene ID hsa-miR-424-5p Hypoxia and angiogenesis HIF1A MIRT005926 CUL2 MIRT005927 Cell cycle CDK6 MIRT000938 CCND1 MIRT000941 CCNE1 MIRT000936 CCND3 MIRT000937 hsa-miR-377 MAPK pathway PPM1A MIRT000990 PI3K-akt pathway PAK1 MIRT000991 HIF1A: Hypoxia-inducible factor 1A; CUL2: Cullin 2; CDK: Cyclin-dependent kinase; CCND1: Cyclin D1; CCNE1: Cyclin E1; CCND3: Cyclin D3; MAPK: Mitogen-activated protein kinase; PPM1A: Protein phosphatase magnesium-dependent 1A; PI3K: Phosphatidyl inositol 3'-kinase; PAK1: p21-activated kinase 1.
In well-studied mammalian systems, the physiological response to hypoxia begins with hypoxia-inducible factor 1 (HIF-1), a transcription factor that is composed of subunits HIF1A and HIF1B (reviewed in Guillemin and Krasnow, 1997).
HIF1A is associated with overexpression of other angiogenic growth factors such as formation of unstable/leaky vasculature (Hadjipanayi and Schilling, 2013).
HIF1[alpha] protein level was assayed using HIF1A Human ELISA kit (Abcam) according to the manufacturer's protocol.
3B); DIO1, deiodinase, iodothyronine, type I; VHL, von Hippel--Lindau tumor suppressor, E3 ubiquitin protein ligase; HIF1A, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); KLK10, kallikrein-related peptidase 10; KLK1, kallikrein 1; KLK15, kallikrein-related peptidase 15.
Xu relied on the gene HIF1A as a biomarker of the amount of molecular oxygen in a cell.
HIF1A is a transcription factor that can be thought of as a cellular oxygen sensor.
Under hypoxic conditions, HIF1A is stabilized and forms a transcription complex.
Transcription factor HIF1A [16] and MYC oncoprotein [17] are involved in upregulation of glucose transporters and many enzymes involved in glycolysis.
Finally, a study by Lidgren et al (160) revealed high expression of HIF1A to be an independent, negative prognosticator in ccRCC.
Details on the measurement of mRNAs encoded by CDH16 [6] (cadherin 16, KSP-cadherin), HIF1A [hypoxiainducible factor 1, a subunit (basic helix-loop-helix transcription factor)], HPRT1 (hypoxanthine phosphoribosyltransferase 1), PPIA [peptidylprolyl isomerase A (cyclophilin A)], KLK3 (kallikrein-related peptidase 3; also known as PSA), and TBP (TATA box binding protein) are provided in Supplemental Text 1, Table 2, A and B, and Fig.