HIF1A


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HIF1A

A gene on chromosome 14q23.2 that encodes hypoxia-inducible factor-1 (HIF1), a transcription factor produced by mammalian cells cultured under reduced oxygen tension, which plays an essential role in homeostatic responses to hypoxia, activating the transcription of over 40 genes including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.

HIF1 plays an essential role in embryonic vascularisation, tumour angiogenesis and pathophysiology of ischaemic disease. HIF1 is a heterodimer composed of an alpha subunit (encoded by HIF1A) and a beta subunit (aryl hydrocarbon receptor nuclear translocator) encoded by ARNT.

Molecular pathology
Overexpression of a natural antisense transcript (aHIF) of HIF1A is associated with nonpapillary renal carcinomas.
References in periodicals archive ?
They identified two proteins that appear to be involved: the transcription factor HIF1a and the signalling protein mTORC1, which both show less activity in diabetes.
(32) Chromosome 14q losses (HIF1A on 14q23.2 and PHD1-EGLN on 14q13.2) and 5q gains are frequently seen in CCRCC (32); 5q gains were present almost all cases reclassified as CCRCC in this study.
After the treatment with gemcitabine or combination of FA and gemcitabine, the expression levels of important genes associated with metastasis including MMP-2, MMP-9, TIMP-1, TIMP-2, CDH1, CDH2, COL4A2, VEGF and HIF1A were determined using qPCR analysis.
Genetic polymorphisms in HIF1A are associated with prostate cancer risk in a Chinese population.
To better determine the synergy between hypoxia and OATPs in HCC, we analyzed the expression levels of HIF1a and OATP1B3 in three different HCC PDX tissues from an HCC patient sample and found high expression of both proteins (Figure 6(a)).
SIRT1 deacetylates and inactivates p53 and HIF1A, active liver X receptor proteins, peroxisome proliferator-activated receptor [gamma], and NFKB1 to promote cell proliferation [29]; RAS signaling, the excessive activation of which is associated with colon cancer initiation, is reported to promote cancer development in diabetes [30].
Recent studies have demonstrated that some molecular factors, such as the BMP family, HIF1a, and scleraxis, have a key role in inducing ectopic bone formation [7,14]; however, several issues remain to be elucidated.
Alam et al., "Accumulation of Krebs cycle intermediates and over-expression of HIF1a in tumours which result from germline FH and SDH mutations," Human Molecular Genetics, vol.
Raffa et al., "Exosomal HIF1a supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes," Oncogene, vol.
It has been established that the activation of HIF1a was related with less inflammatory state mediated by downregulation of NF-[kappa]B activation in periapical tissue [43], so we think that the NF-[kappa]B molecular pathway could be downregulated in the submandibular gland of CCH animals, enabling a better response to hypoxia (Figure 8).
Consequently, low-oxygen content in the tumor induces the hypoxia-inducible factor 1 (HIF1A) stabilization.
Dietary obesity-associated Hif1a activation in adipocytes restricts fatty acid oxidation and energy-expenditure via suppression of the Sirt2-NAD + system.