HIF1A

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HIF1A

A gene on chromosome 14q23.2 that encodes hypoxia-inducible factor-1 (HIF1), a transcription factor produced by mammalian cells cultured under reduced oxygen tension, which plays an essential role in homeostatic responses to hypoxia, activating the transcription of over 40 genes including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.

HIF1 plays an essential role in embryonic vascularisation, tumour angiogenesis and pathophysiology of ischaemic disease. HIF1 is a heterodimer composed of an alpha subunit (encoded by HIF1A) and a beta subunit (aryl hydrocarbon receptor nuclear translocator) encoded by ARNT.

Molecular pathology
Overexpression of a natural antisense transcript (aHIF) of HIF1A is associated with nonpapillary renal carcinomas.
References in periodicals archive ?
Estas evidencias sugieren que las enzimas lisil-oxidasas (LOX) son responsables de las propiedades invasivas de las celulas tumorales hipoxicas inducidas por el factor HIF1 (105, 106).
El factor de transcripcion Twist es un regulador de la gastrulacion, y esta implicado como mediador de la metastasis en el cancer (110), por lo que la co-expresion de HIF1, Twist y Snail, en tumores primarios, promueve la metastasis en respuesta a hipoxia intra-tumoral (111).
HIF1 alpha induces the requeriment of bone marrowderived vascular modulatory cells to regulate tumor angiogenesis and invasion.
Similar to the other Sirts, Sirt7 has been considered a tumor suppressor and its activity is mediated by the negative regulation of HIF1 and HIF2 transcription [44].
Current and Emerging Prognostic Parameters in Clear Cell Renal Cell Carcinoma (ccRCC) Current Prognostic Parameters in ccRCC Patient factors Age Sex Pathologic factors pTNM Histologic type Fuhrman grade LVI Tumor necrosis Clinical factors ECOG performance status Hgb level Serum lactate dehydrogenase Emerging Potential Molecular Prognostic and Predictive Parameters in ccRCC Hypoxia inducible HIF1 CAIX CAXII CXCR4 VEGF/VEGFR-R ILGF1 Cell adhesion markers EpCAM E-cadherin [alpha]-Catenin Catenin-6 Proliferation markers Ki-67 MCM2 Cell cycle regulators Cyclin p27 Apoptosis regulators p53 Bcl2 Smac/DIABLO mTOR pathway PTEN Akt Phos S6k an Abbreviations: ECOG, Eastern Cooperative Oncology Group; Hgb, hemoglobin; LVI, lamina propria invasion.
HIF1 is a heterodimer consisting of oxygen dependent transcriptional factors HIF1A and ARNT, or HIF1B.
The intraretinal tumor expressed VEGF, which did not appear to be mediated by HIF1 or iNOS, the most common pathways of ischemia mediated angiogenesis.
Abstract No 4002: Use of intratumoral mRNA expression of genes involved in angiogenesis and HIF1 pathway to predict outcome to VEGFR tyrosine kinase inhibitor (TKI) in patients enrolled in CONFIRM1 and CONFIRM2
Because hypoxia regulates angiogenesis, the hypothesis was tested that high intratumoral mRNA levels of genes involved with hypoxia such as HIF1, LDHA and Glut1, as well as genes involved in angiogenesis such as vascular endothelial growth factor A (VEGF) and its receptors, VEGFR1 and VEGF2, are predictive of outcome.
Chromatin immunoprecipitation studies showed that HIF1 bound to murine and human hepcidin promoters.