SETD2

(redirected from HIF-1)

SETD2

A gene on chromosome 3p21.31 that encodes a ubiquitously expressed histone methyltransferase that specifically methylates Lys-36 of histone H3. Lys-36 methylation is a specific tag for epigenetic transcriptional activation. SETD2 likely plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. It may also act as a promoter-binding transcription activator.
References in periodicals archive ?
HIF-1 binds to a region (5'-CGTG-3 ') located in the promoter region of the target gene and known as the hypoxic response element.
Other conditions showed that elevated PGC-1[alpha] regulates the stabilization of HIF-1 in skeletal muscle (21).
Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism.
Aerpio Pharmaceuticals announced an exclusive global license agreement with a wholly owned subsidiary of Gossamer Bio, Inc., GB004, for the development and commercialization of Aerpio's HIF-1 alpha stabilizer, AKB-4924, along with other related compounds.
Hypoxia-Inducible Factor-1 (HIF-1), a heterodimeric transcription factor, is an essential part of the cellular response to the hypoxic condition (5).
Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival.
The study discovered that lowered levels of oxygen - known as hypoxia - stimulates the production of a protein called HIF-1, which drives repair of the womb lining.
Semenza, "HIF-1: mediator of physiological and pathophysiological responses to hypoxia," Journal of Applied Physiology, vol.
The transcription factor HIF-1 is composed of two subunits, HIF-1[alpha] and HIF-[beta] or aryl hydrocarbon receptor nuclear translocator (ARNT) [14].
Hypoxia-inducible factor-1 (HIF-1) plays an important role in the up-regulation of glycolytic enzymes gene expressions in cells subjected to hypoxia [7] or in skeletal muscle subjected to exercise [8].
HIF transcription factors (HIF-1 and HIF-2) act as heterodimers comprising an alpha and beta subunit.