binds to a region (5'-CGTG-3 ') located in the promoter region of the target gene and known as the hypoxic response element.
Other conditions showed that elevated PGC-1[alpha] regulates the stabilization of HIF-1
in skeletal muscle (21).
Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1
) dependent mechanism.
Aerpio Pharmaceuticals announced an exclusive global license agreement with a wholly owned subsidiary of Gossamer Bio, Inc., GB004, for the development and commercialization of Aerpio's HIF-1
alpha stabilizer, AKB-4924, along with other related compounds.
Hypoxia-Inducible Factor-1 (HIF-1
), a heterodimeric transcription factor, is an essential part of the cellular response to the hypoxic condition (5).
Hypoxia Inducible Factor 1-Alpha (HIF-1
Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival.
The study discovered that lowered levels of oxygen - known as hypoxia - stimulates the production of a protein called HIF-1
, which drives repair of the womb lining.
: mediator of physiological and pathophysiological responses to hypoxia," Journal of Applied Physiology, vol.
The transcription factor HIF-1
is composed of two subunits, HIF-1[alpha] and HIF-[beta] or aryl hydrocarbon receptor nuclear translocator (ARNT) .
Hypoxia-inducible factor-1 (HIF-1
) plays an important role in the up-regulation of glycolytic enzymes gene expressions in cells subjected to hypoxia  or in skeletal muscle subjected to exercise .
HIF transcription factors (HIF-1
and HIF-2) act as heterodimers comprising an alpha and beta subunit.
Hydroxylation of HIF-1
: Oxygen sensing at the molecular level.