SETD2

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SETD2

A gene on chromosome 3p21.31 that encodes a ubiquitously expressed histone methyltransferase that specifically methylates Lys-36 of histone H3. Lys-36 methylation is a specific tag for epigenetic transcriptional activation. SETD2 likely plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. It may also act as a promoter-binding transcription activator.
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HIF-1 is a heterodimer transcription factor consisting of [alpha] and [beta] subunits.
The study discovered that lowered levels of oxygen - known as hypoxia - stimulates the production of a protein called HIF-1, which drives repair of the womb lining.
Therefore, signaling pathways of hypoxia-induced autophagy can be divided into two: HIF-1 dependent pathway and HIF-1 independent pathway (Figure 1).
The HIF-1 is composed of a constitutively expressed HIF-i[beta] subunit and an [O.
It has been reported that HIF-1 regulated target genes to adapt to hypoxia in mammals and humans.
9-11 HIF-1 is thought to be critical mediator of the transcriptional response to hypoxia and the expression of HIF-1a, the main activity unit, is regulated by oxygen availability.
HIF-1 (hypoxia inducible factor-1), a kind of hydrocarbon nuclear translators, plays an important role in oxygen homeostasis [7] and consists of two subunits, HIF-1 alpha and HIF-1 beta.
The transcription factor complexes HIF-1 (HIF-1[alpha]/HIF-1[beta]) and HIF-2 (HIF-2[alpha]/HIF-1[beta]) recruit cofactors such asp300/CBP (cAMP-response element binding protein) and bind to hypoxia-responsive elements of target gene DNA.
Tenders are invited for Supply of SC-13515 HIF-1 alfa (28b), SC-2357 Mouse anti-rabbit IgG-HRP, SC-358917 rabbit anti-mouse IgG-HRP
In a study published online in the journal Cell, researchers found that a protein called HIF-1 alpha plays a key role in the development of insulin resistance and type 2 diabetes in obese mice.
Earlier the group determined that HIF-1 helps breast tumor cells survive the low-oxygen conditions in which they often live, and spread to other parts of the body such as the lungs.