In our previous study on women diagnosed with LSIL on cytology, those with infection of a non-16/18 hrHPV genotype were more likely to have persistent disease or to progress to HGCL. (14) This suggests that these women with LSIL cytology and non-16/18 HPV infection tended to harbor high-grade lesions and were more likely to be underdiagnosed because of deceptive lower-grade cytomorphology.
Women infected with these genotypes may harbor HGCL despite deceptive lower-grade cytomorphology.
Association of human papilloma virus (HPV) infection patterns with cytologic detection of low-grade cytologic lesion (LGCL) and high-grade cytologic lesions (HGCL) in women with biopsy-confirmed, high-grade squamous intraepithelial lesions.
(%) HPV-16 9 (14) 33 (53) HPV-18 1 (16) 2 (33) Non-16/18 hrHPV 7 (6) 75 (70) Mixed hrHPV 1 (2) 31 (77) hrHPV Test HGCL, No.
The cervical lesions detected on Pap tests were categorized into 2 general groups: low-grade cervical lesions, encompassing atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSILs), and high-grade cervical lesions (HGCLs), including ASC, cannot rule out HSILs; atypical glandular cells; HSILs, and carcinomas.