HFE protein


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Related to HFE protein: Hepcidin

HFE protein

A protein normally found intracellularly in duodenal crypt enterocytes and the placenta. It is closely associated with transferrin receptors for iron and regulates iron absorption. HFE is a homologue of class I major histocompatibility complex (MHC) molecules. The C2824 and H63D mutations on chromosome 6 in the HFE gene cause hemochromatosis.
See also: protein
References in periodicals archive ?
The gene that encodes for hepcidin is designated as HAMP, and its expression may be regulated by HFE protein.
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum.
This can be related to the HFE protein as a cell-surface receptor for some infectious agents (58) or to the relative iron deficiency that occurs in the macrophages in the presence of the C282Y sequence variant, and offers a possible protection against many virulent species of bacteria that multiply mainly in iron-rich macrophages, such as Mycobacterium tuberculosis and Yersinia pestis (59).
The hemochromatosis (HFE) gene encodes the HFE protein, a transmembrane glycoprotein that is implicated in the modulation of iron uptake from the diet (1).