HEY2


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Related to HEY2: HEY1, PubMed

HEY2

A gene on chromosome 6q21 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEY2 is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It interacts with ARNT, GATA4, GATA6, HES1, HEYL, HDAC1, NCOR1 and SIN3A.
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Type II EmCa from African-American patients showed significantly higher expression levels of Notch receptors (Notch1 and Notch4), ligands (JAG1 and DLL4) and targets (Survivin, Hey2, IL-1R tI, and OB-R).
Inhibition of leptin signaling decreased tumor levels of Notch ligands, receptors and activated NICD together with Notch targeted genes: survivin and Hey2. Moreover, PEG-LPrA2 treatment reduced the levels of several leptin-induced molecules within DMBA-MT: OB-R, IL-1R tl, VEGF/VEGFR2, bcl-2, HIF-la and NFkB (p50 and p105).
Notch signaling input is crucial in the specification of hemogenic endothelium from arterial endothelium, and this specification appears to be mediated by Gata2, Hes1, Hes5, and Hey2; all of which are Notch target genes [78].