HEY1

HEY1

A gene on chromosome 8q21 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEY1 is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It is expressed in the mesoderm, CNS, kidneys, heart, nasal epithelium and limbs, and it interacts with HES1, HEYL, HDAC1, NCOR1, SIN3A, GATA4, GATA6 and CCDC89/BOIP.
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In line with this finding, it has been shown that all-trans RA can repress neurosphere growth and induce the differentiation of glioblastoma stem cells as evidenced by the downregulation of HES2, HEY1, and HEY2, which are the targets of the Notch signaling pathway.
Among them, we found the principal components of major regulatory clusters, involving inflammatory responses (IFNy, IL6, several members of the interleukin 1 pathway, including ILIA, IL1B, IL1RN, and the TNF pathway members TNF, TNFAIP6, TNFSF15, TNFRSF9), angiogenesis (CXCL10, PTGS2), immune regulation (CD80, CD274, CSF3, IL23R), leukocyte chemotaxis (CCL2, CCL3, CCL4, CCL20, CCL23, CCL3L3, CXCL1, CXCL2, CXCL5, CXCL9), transcriptional regulation (EGR1, GATA6, HEY1), proliferation (CDKN2B, FGFR1), adhesion (ITGB8), extracellular matrix remodeling (ADAMTS4), cell-cell communication (GJB2), cell signaling (EDNRB, IRS1, RIN2), ion transmembrane transport (KCNJ2, CLIC4), and response to oxidative stress (SOD2).
Critical myogenic genes involved in myotube differentiation including Pax7, myogenin (MyoG), myosin heavy chain 1 (MYH1), hairy/enhancer-of-split related with YRPW motif protein 1 (Hey1), DNA-binding protein inhibitor ID1 (ID1), and activin A receptor type I (ACVR1) were precipitously downregulated in MyoD KO QM7#4 cells (Table 2).
Feng, "Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1," International Journal of Molecular Medicine, vol.
Experiment with STZ-induced diabetes mouse displayed that the expressions of Jag, Notch, and ICN1 were increased immediately and the downstream component, such as Hes1 and Hey1, were activated.
This complex mediates the transcription of downstream target genes such as Hes1, Hey1, and cyclin D [8].
In epithelial cells, for example, Hey1 was found to be required for TGF-[beta]-induced EMT and migration [94].
Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.
AT reduces the expression of Hedgehog pathway target genes, such as PTCH1, N-Myc, and GLI2, but also the expression of the Notch pathway target genes HES1, HES5, and HEY1 and that of the pluripotency factor SOX2 [103].
The second class contains genes that control cell differentiation during the development of a number of tissues (SOX11, SOX18, HEY1, CART1, PRX2, SMAD7, ID1).