HEY1

A gene on chromosome 8q21 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEY1 is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It is expressed in the mesoderm, CNS, kidneys, heart, nasal epithelium and limbs, and it interacts with HES1, HEYL, HDAC1, NCOR1, SIN3A, GATA4, GATA6 and CCDC89/BOIP.

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In line with this finding, it has been shown that all-trans RA can repress neurosphere growth and induce the differentiation of glioblastoma stem cells as evidenced by the downregulation of HES2, HEY1, and HEY2, which are the targets of the Notch signaling pathway.

9-cis-Retinoic Acid and 1,25-dihydroxy Vitamin [D.sub.3] Improve the Differentiation of Neural Stem Cells into Oligodendrocytes through the Inhibition of the Notch and Wnt Signaling Pathways

Among them, we found the principal components of major regulatory clusters, involving inflammatory responses (IFNy, IL6, several members of the interleukin 1 pathway, including ILIA, IL1B, IL1RN, and the TNF pathway members TNF, TNFAIP6, TNFSF15, TNFRSF9), angiogenesis (CXCL10, PTGS2), immune regulation (CD80, CD274, CSF3, IL23R), leukocyte chemotaxis (CCL2, CCL3, CCL4, CCL20, CCL23, CCL3L3, CXCL1, CXCL2, CXCL5, CXCL9), transcriptional regulation (EGR1, GATA6, HEY1), proliferation (CDKN2B, FGFR1), adhesion (ITGB8), extracellular matrix remodeling (ADAMTS4), cell-cell communication (GJB2), cell signaling (EDNRB, IRS1, RIN2), ion transmembrane transport (KCNJ2, CLIC4), and response to oxidative stress (SOD2).

Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice

Critical myogenic genes involved in myotube differentiation including Pax7, myogenin (MyoG), myosin heavy chain 1 (MYH1), hairy/enhancer-of-split related with YRPW motif protein 1 (Hey1), DNA-binding protein inhibitor ID1 (ID1), and activin A receptor type I (ACVR1) were precipitously downregulated in MyoD KO QM7#4 cells (Table 2).

Myotube differentiation in clustered regularly interspaced short palindromic repeat/Cas9-mediated MyoD knockout quail myoblast cells

Feng, "Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1," International Journal of Molecular Medicine, vol.

miR-155 Inhibits Mouse Osteoblast Differentiation by Suppressing SMAD5 Expression

Experiment with STZ-induced diabetes mouse displayed that the expressions of Jag, Notch, and ICN1 were increased immediately and the downstream component, such as Hes1 and Hey1, were activated.

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

This complex mediates the transcription of downstream target genes such as Hes1, Hey1, and cyclin D [8].

Notch1 Pathway Protects against Burn-Induced Myocardial Injury by Repressing Reactive Oxygen Species Production through JAK2/STAT3 Signaling

In epithelial cells, for example, Hey1 was found to be required for TGF-[beta]-induced EMT and migration [94].

Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.

Role of Notch signaling in the mammalian heart

AT reduces the expression of Hedgehog pathway target genes, such as PTCH1, N-Myc, and GLI2, but also the expression of the Notch pathway target genes HES1, HES5, and HEY1 and that of the pluripotency factor SOX2 [103].

Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications

The second class contains genes that control cell differentiation during the development of a number of tissues (SOX11, SOX18, HEY1, CART1, PRX2, SMAD7, ID1).

Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth

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