HEY1

A gene on chromosome 8q21 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEY1 is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It is expressed in the mesoderm, CNS, kidneys, heart, nasal epithelium and limbs, and it interacts with HES1, HEYL, HDAC1, NCOR1, SIN3A, GATA4, GATA6 and CCDC89/BOIP.

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HAND1
HAND2
HEYL

References in periodicals archive ?

The second class contains genes that control cell differentiation during the development of a number of tissues (SOX11, SOX18, HEY1, CART1, PRX2, SMAD7, ID1).

Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth

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