HES4

HES4

A gene on chromosome 1p36.33 that encodes a DNA-binding repressor of genes that require a basic helix-loop-helix (bHLH) for their transcription. This transcription repression requires the formation of a complex with a co-repressor protein of the Groucho/TLE family.
References in periodicals archive ?
Hemming et al., "Novel basic helix-loop-helix transcription factor Hes4 antagonizes the function of Twist-1 to regulate lineage commitment of bone marrow stromal/stem cells," Stem Cells and Development, vol.