HES2

HES2

A gene on chromosome 1p36.31 that encodes a DNA-binding repressor of genes that require a basic helix-loop-helix (bHLH) for their transcription. This transcription repression requires the formation of a complex with a co-repressor protein of the Groucho/TLE family. HES2 is expressed in placenta and in cancers of the pancreas, colon, cervix, and head and neck.
References in periodicals archive ?
In line with this finding, it has been shown that all-trans RA can repress neurosphere growth and induce the differentiation of glioblastoma stem cells as evidenced by the downregulation of HES2, HEY1, and HEY2, which are the targets of the Notch signaling pathway.
Componentes de la via NOTCH canonica por especies (12, 22) Components Aves Mamiferos Notch1 Notch1 Receptores Notch2 Notch2 Notch3 Notch4 Serrate1 (Jagged1) Jagged1 Serrate2 (Jagged2) Jagged2 Ligandos Delta1 Delta1 Delta4 Delta3 Delta4 Hairy1 (Hes1) Hes1 - 7 Hairy2 (Hes2) Hairy5 (Hes) Genes blanco Hairy6 (Hes6) Hey1 Hey1 Hey2 Hey2 HeyL HeyL Proteinas Lunatic, manic and Lunatic, manic and reguladoras radical fringe radical fringe Components Drosophila M.
Notch1 Notch1 Receptors Notch2 NOTCH Notch2 Notch3 Notch4 Serrate1 (Jagged1) Jagged1 Serrate Serrate2 (Jagged2) Jagged2 Delta Ligands Delta1 Delta1 Delta4 Delta3 Delta4 Hairy1 (Hes1) Hes1 - 7 Hairy2 (Hes2) Hairy5 (Hes) Target genes Hairy6 (Hes6) E (psl) bHLH Hey1 Hey1 Hey2 Hey2 HeyL HeyL Regulatory Lunatic, manic and Lunatic, manic and Fringe proteins radical fringe radical fringe Components C.