HES1


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HES1

A gene on chromosome 3q28-q29 that encodes a DNA-binding repressor of genes that require a basic helix-loop-helix (bHLH) for their transcription. This transcription repression requires the formation of a complex with a co-repressor protein of the Groucho/TLE family. HES1 is thought to downregulate myogenesis by inhibiting the functions of MYOD1 and ASH1, and may play a role in a functional FA core complex response to DNA cross-link damage.
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And K13 mRNA expression was inhibited in a time-dependent manner, whereas Hes1 mRNA expression was decreased in concentration- and time-dependent manners.
C, The protein levels of Hes1, N-cadherin, E-cadherin in tumor cells were examined with Western blot.
Otro de los genes pertenecientes a la via de senalizacion NOTCH implicados en el desarrollo de estructuras craneofaciales como el paladar, es el gen Hes1. (15) Ratones con mutaciones homocigotas [Hes1.sup.-/-], presentan alteraciones durante el proceso de palatogenesis secundaria, caracterizado por un crecimiento deficiente y una prematura elevacion y reorientacion horizontal de las crestas palatinas, lo cual genera un paladar hendido, dado que el deficiente tamano de las crestas palatinas no permite que estas puedan contactar y fusionarse en la mayoria de los mutantes.
The data showing TCDD-induced alterations of Notch and Hes1 expression combined with the shift in the proportion of cells in c-[Kit.sup.+]DC[F.sup.int] to c-[Kit.sup.+]DC[F.sup.hi] are suggestive of premature maturation of the hematopoietic stem cell pool, which effectively depletes the number of l ong-t erm hematopoietic stem cells.
Normal mice were subjected to burn injury, and the protein expression of Notch1 and Hes1 in myocardium tissue was examined at various time points from 0 to 24 h.
The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.
Reverse Transcription and qPCR Assay for GATA4, cTnI, Notch1, and Hes1 mRNAs.
After fixation with cold acetone for 10 min, the tissues were incubated with 10% goat serum containing 0.1% Triton X-100 and 1% BSA (room temperature (RT); 1h) for Cytokeratin 19 (CK19) and with 1% BSA and goat serum (RT; 30 min) for hairy enhancer of split 1 (Hes1) [11].
(29) The tissue microarrays with densities of 56 spots/[cm.sup.2] were sectioned to 5-[micro]m thickness for immunohistochemical profiling of Notch1, Notch2, and Hes1 expression and intracellular distribution, respectively.
Gene Microarray Q-PCR PLK2 2.2 [+ or -] 0.1 1.8 [+ or -] 0.4 SGK 3.9 [+ or -] 0.2 3.4 [+ or -] 1.5 SE20-4 2.5 [+ or -] 0.2 2.4 [+ or -] 0.2 BHLHB2 2.8 [+ or -] 0.1 4.2 [+ or -] 0.2 CCNL1 3.1 [+ or -] 0.2 2.6 [+ or -] 0.4 C8FW 4.0 [+ or -] 0.2 2.3 [+ or -] 0.2 HES1 8.9 [+ or -] 0.9 1.7 [+ or -] 0.4 FOSB 52 [+ or -] 1.8 2.6 [+ or -] 0.1 DUSP2 17 [+ or -] 0.0 1.7 [+ or -] 0.1 PPP1R15A 4.6 [+ or -] 0.1 0.9 [+ or -] 0.2 NFKB1A 3.7 [+ or -] 0.3 0.9 [+ or -] 0.2 NEU1 2.2 [+ or -] 0.1 1.1 [+ or -] 0.1 DDAH1 -2.2 [+ or -] 0.0 -1.8 [+ or -] 0.1 NFATC1 -2.9 [+ or -] 0.0 -1.8 [+ or -] 0.2 NVKB1 -2.8 [+ or -] 0.0 -5.2 [+ or -] 0.8 Data are mean [+ or -] SD of three independent measurements, which represent fold change on [log.sub.2] scale compared with data obtained from control group.
They revealed that EVs from MSCs contain mRNAs involved in transcription (e.g., MDFIC, POU3F1), angiogenesis (e.g., HES1, TCF4), adipogenesis (e.g., CEBPA, KLF7), and transforming growth factor- (TGF-) [beta] signaling (e.g., TGFB1, TGFB3).
Ishikawa, "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression," Biochemical and Biophysical Research Communications, vol.