HES1(redirected from HES-1)
HES1A gene on chromosome 3q28-q29 that encodes a DNA-binding repressor of genes that require a basic helix-loop-helix (bHLH) for their transcription. This transcription repression requires the formation of a complex with a co-repressor protein of the Groucho/TLE family. HES1 is thought to downregulate myogenesis by inhibiting the functions of MYOD1 and ASH1, and may play a role in a functional FA core complex response to DNA cross-link damage.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.