HES1

(redirected from HES-1)

HES1

A gene on chromosome 3q28-q29 that encodes a DNA-binding repressor of genes that require a basic helix-loop-helix (bHLH) for their transcription. This transcription repression requires the formation of a complex with a co-repressor protein of the Groucho/TLE family. HES1 is thought to downregulate myogenesis by inhibiting the functions of MYOD1 and ASH1, and may play a role in a functional FA core complex response to DNA cross-link damage.
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In Figure 2(a) of the published article entitled "miR-1-Mediated Induction of Cardiogenesis in Mesenchymal Stem Cells via Downregulation of Hes-1," [1] the authors admit to being careless in altering nonspecific belts, stains, or scratches in the Nkx2.5, cTnT, and CX43 panels.
(a) Expression of Notch-1, Notch-2, Notch-4, Dll-1, Dll-4, Jag-1, Hes-1, and Hey-1 were detected on MSCs.
Notch-1 and its target genes Hes-1, Hey-1, Hey-2 expression in U2OS and MG-63 cells treated with increasing concentrations of curcumin for 48 hours, were assessed using real time RT-PCR analysis.