KCNH2

(redirected from HERG1)

KCNH2

A gene on chromosome 7q36.1 that encodes an alpha subunit of voltage-gated, potassium channels of the eag family.

Molecular pathology
KCNH2 mutations can cause long QT syndrome type 2.
References in periodicals archive ?
Kcnh2, the gene that encodes expression of KCNH2 protein (also known as hERG1) that encodes the hERG channel, was not significantly altered in diabetic SAN.
hERG1 channels drive tumour malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma.
Compared to the well-known function of human ERG1 (HERG1) channels in long QT syndrome in cardiac arrhythmia, the physiological roles of EAG channels remain largely unknown [5].
For instance, PI[P.sub.2] increases currents through hERG1 possibly via a short region rich in positively charged residues ([sup.883]RQRKRKLSFRRR[sup.894]) in the intracellular C terminus [49].
[14.] Durdagi S, Deshpan S, Duff HJ, Noskov SY (2012) Modeling of open; closed; and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.
Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway.