KCNH2

(redirected from HERG1)

KCNH2

A gene on chromosome 7q36.1 that encodes an alpha subunit of voltage-gated, potassium channels of the eag family.

Molecular pathology
KCNH2 mutations can cause long QT syndrome type 2.
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References in periodicals archive ?
Kcnh2, the gene that encodes expression of KCNH2 protein (also known as hERG1) that encodes the hERG channel, was not significantly altered in diabetic SAN.
Compared to the well-known function of human ERG1 (HERG1) channels in long QT syndrome in cardiac arrhythmia, the physiological roles of EAG channels remain largely unknown [5].
For instance, PI[P.sub.2] increases currents through hERG1 possibly via a short region rich in positively charged residues ([sup.883]RQRKRKLSFRRR[sup.894]) in the intracellular C terminus [49].
[14.] Durdagi S, Deshpan S, Duff HJ, Noskov SY (2012) Modeling of open; closed; and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding.
Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway.