Kcnh2, the gene that encodes expression of KCNH2 protein (also known as hERG1
) that encodes the hERG channel, was not significantly altered in diabetic SAN.
Compared to the well-known function of human ERG1 (HERG1) channels in long QT syndrome in cardiac arrhythmia, the physiological roles of EAG channels remain largely unknown .
For instance, PI[P.sub.2] increases currents through hERG1 possibly via a short region rich in positively charged residues ([sup.883]RQRKRKLSFRRR[sup.894]) in the intracellular C terminus .
[14.] Durdagi S, Deshpan S, Duff HJ, Noskov SY (2012) Modeling of open; closed; and open-inactivated states of the hERG1
channel: structural mechanisms of the state-dependent drug binding.
Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1
channels and of the VEGF-A pathway.