KCNH2

(redirected from HERG)
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KCNH2

A gene on chromosome 7q36.1 that encodes an alpha subunit of voltage-gated, potassium channels of the eag family.

Molecular pathology
KCNH2 mutations can cause long QT syndrome type 2.
References in periodicals archive ?
Electrophysiologic and biophysical characterization of expressed HERG in Xenopus oocytes established that HERG encodes the rapidly activating delayed-rectifier potassium current [I.
Finally, the researchers identified HERG mutations in six families with long QT syndrome.
Genes associated with potassium channelopathies in humans Channelopathies Genes involved Anderson--Tawil syndrome KCNJ2 Episodic ataxia with myokymia type 1 KCNA1 Long QT syndrome type 1 KVLQT1 Long QT syndrome type 2 HERG Long QT syndrome type 5 MINK Long QT syndrome type 7 KCNJ2 Familial hyperinsulinemia of infancy KCNJ11, ABCC8 Source: Refs 22, 32
Erythromycin causes QT interval prolongation and blocks potassium channels encoded by the HERG gene.
Among these patients, 20-40% may have mutations in KCNH2 encoding the HERG [alpha]-subunit of the HERG/MiRP1 channel conducting the [I.
17) recently described HERG mutations in 17% of patients presenting with CAVB and prolonged QT interval (>600 ms) in a French population.
Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes.
Third, the variety of cardiac function abnormalities we observed with both model tricyclic PAHs and weathered crude oil suggests several potential targets in the myocardium, which, in addition to HERG potassium channels, includes sarcoplasmic or plasma membrane calcium channels, as well as gap junctions.
The exhibit takes the viewer on a journey through time and space, from Hergs well-known ligne claire to groundbreaking structural innovations by artists such as Fred (Philmon), and to the new scene of French comics today, with images from cutting-edge artists such as Julie Maroh, David B.