Based on these results, Tripos' Center for Advanced Technology in San Francisco will develop the predictive model and employ it to examine client's data resulting from ChanTest's analysis of lead candidates to identify any
hERG ion channel liability.
Electrophysiologic and biophysical characterization of expressed
HERG in Xenopus oocytes established that
HERG encodes the rapidly activating delayed-rectifier potassium current [I.sup.Kr] (Figure 3).[43,44] Electrophysiologic studies of LQTS-associated mutations showed that they act through either a loss-of-function or a dominant-negative mechanism.[45] In addition, protein trafficking abnormalities have been shown to occur.[46,47] This channel has been shown to coassemble with [Beta]-subunits for normal function, similar to that seen in [I.sub.Ks].
Further research suggested that while
HERG's protein product turns up on other cells of the body, it is usually found on the surface of heart cells.
Other reports suggested that ginsenoside Rg1 increased the outward
hERG current, and it provided potential protection against myocardial infarction [33].
Another assessed toxic effect was the
hERG inhibition, which is an ion channel that, when inhibited, is related to cardiovascular damage (32).
Inhibitory effects of a bisbenzylisoquinline alkaloid dauricine on
HERG potassium channels.
OTHER than a dizzying motorcycle ride through the alleys of a Moroccan marketplace, Stephen Spielberg's big screen adaption of
Herg's fearless reporter is a damp squib.
And of course, there's Tintin, a work of genius by the Belgian comic writer and artist
Herg and the main reason for my trip, organised to mark Wednesday's release of the new film version overseen by Steven Spielberg.
SINCE his first appearance in 1929 Tintin, creator
Herg's plucky reporter with the distinctive ginger quiff, has travelled the world uncovering dastardly deeds with intrepid pooch Snowy by his side.
And nobody is more excited about all this than a one-time roving reporter and lifelong Tintin devotee who is coming to the North East at the weekend to talk about the new film, about Tintin creator
Herg and about his own book, Tintin: the Complete Companion, newly reissued by publisher Egmont.
REVIEW The Adventures of Tintin - The Secret of the Unicorn 3D (PG) WRITING under the pen name of
Herg, it's 82 years since the world was introduced to Les Aventures de Tintin created by Belgian artist Georges Rmi (1907-1983).
The company said that the certificate states that WuXi's BAS facility in Shanghai is able to carry out ADME (absorption, distribution, metabolism, and excretion) studies, toxicokinetic and pharmacokinetic studies and
hERG assay and biomarker studies with respect to OECD and EU principles of Good Laboratory Practice.