KCNH2

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KCNH2

A gene on chromosome 7q36.1 that encodes an alpha subunit of voltage-gated, potassium channels of the eag family.

Molecular pathology
KCNH2 mutations can cause long QT syndrome type 2.

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References in periodicals archive ?

Blockade of HERG channels by HIV protease inhibitors.

Amiodarone-induced torsades de pointes in a patient with HIV on combination antiretroviral therapy

Electrophysiologic and biophysical characterization of expressed HERG in Xenopus oocytes established that HERG encodes the rapidly activating delayed-rectifier potassium current [I.

Genotype and Severity of Long QT Syndrome

Finally, the researchers identified HERG mutations in six families with long QT syndrome.

Seizing two genes for fast heartbeat

Genes associated with potassium channelopathies in humans Channelopathies Genes involved Anderson--Tawil syndrome KCNJ2 Episodic ataxia with myokymia type 1 KCNA1 Long QT syndrome type 1 KVLQT1 Long QT syndrome type 2 HERG Long QT syndrome type 5 MINK Long QT syndrome type 7 KCNJ2 Familial hyperinsulinemia of infancy KCNJ11, ABCC8 Source: Refs 22, 32

Potassium channels in health, disease & development of channel modulators

Erythromycin causes QT interval prolongation and blocks potassium channels encoded by the HERG gene.

Pharmacologic agents associated with QT interval prolongation

Among these patients, 20-40% may have mutations in KCNH2 encoding the HERG [alpha]-subunit of the HERG/MiRP1 channel conducting the [I.

Screening for mutations and polymorphisms in the genes KCNH2 and KCNE2 encoding the cardiac HERG/MiRP1 ion channel: implications for acquired and congenital long Q-T syndrome

Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells.

Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response

17) recently described HERG mutations in 17% of patients presenting with CAVB and prolonged QT interval (>600 ms) in a French population.

Repolarization characteristics and incidence of torsades de Pointes in patients with acquired complete atrioventricular block

Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes.

Berberine alleviates ischemic arrhythmias via recovering depressed [I.sub.to] and [I.sub.ca] currents in diabetic rats

Third, the variety of cardiac function abnormalities we observed with both model tricyclic PAHs and weathered crude oil suggests several potential targets in the myocardium, which, in addition to HERG potassium channels, includes sarcoplasmic or plasma membrane calcium channels, as well as gap junctions.

Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development

The exhibit takes the viewer on a journey through time and space, from Hergs well-known ligne claire to groundbreaking structural innovations by artists such as Fred (Philmon), and to the new scene of French comics today, with images from cutting-edge artists such as Julie Maroh, David B.