ERBB4

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ERBB4

A gene on chromosome 2q33.3-q34 that encodes a single-pass type-1 membrane protein member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. ERBB4 binds to and is activated by neuregulins and other factors, and it induces various cellular responses, including mitogenesis and differentiation.

Molecular pathology
ERBB4 mutations have been associated with cancer.
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These second-generation drugs are higher-affinity, irreversible EGFR tyrosine kinase blockers that also inhibit HER2 and sometimes HER4 and may have modest activity against T790M or other mutations that cause acquired resistance to first-generation EGFR TKIs.
HER Family of Membrane Receptors Tyrosine Kinase Receptor Activity Major Ligands HER1 (EGFR) Yes EGF, amphiregulin, TGF-a HER2 Yes None HER3 No Heregulin HER4 Yes Heregulin Abbreviations: EGF, epidermal growth factor;EGFR, epidermal growth factor receptor;TGF-a, transforming growth factor a.
Poziotinib is a novel, oral pan-HER inhibitor that irreversibly blocks signaling through the Epidermal Growth Factor Receptor (EGFR, HER) Family of tyrosine-kinase receptors, including HER1 (erbB1; EGFR), HER2 (erbB2), and HER4 (erbB4), and importantly, also HER receptor mutations; this, in turn, leads to the inhibition of the proliferation of tumor cells that overexpress these receptors.
Epidermal growth factor receptor (also called HER1 or ErbB1) belongs to the HER or ErbB family, which also comprises HER2/neu, HER3, and HER4.
As noted above, EGFR is a member of the erbB family of receptor tyrosine kinase proteins, now known to also include HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4).