ERBB2A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming a heterodimer, stabilising ligand binding and enhancing kinase-mediated activation of downstream signalling pathways (e.g., those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase).
ERBB2 amplification and overexpression commonly occurs in breast and ovarian cancers.
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HER-2c-erbB-2, HER-2/neu Oncology An erbB family oncogene related to epidermal growth factor; HER-2 overexpression, espceically breast CA, and stomach CAs, which have a ↓ survival and ↓ time to relapse. See Breast cancer.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.