Also, with a large HER-2
negative patient population that is not eligible for treatment with Herceptin, there is a strong unmet need and opportunity for therapies that are effective in these patients, including those who overexpress HER-2
," Trewartha concludes.
Clearance was given for Invitrogen's SPOT-Light test to count copies of the so-called HER-2
gene in tumor tissue that regulates the growth of cancer cells, the FDA said.
In validating the new method, we also developed a multiplex, single-tube methodology, using aQRT-PCR, to detect HER-2
copy number variations in microdissected breast cancer samples; in formalin-fixed, paraffin-embedded (FFPE) specimens; and in plasma circulating DNA.
Research suggests that the drug halves the chances of the aggressive HER-2
form of breast cancer returning.
Abbott Laboratories, Abbott Park, IL, has received FDA approval for its Vysis PathVysion HER-2
DNA Probe Kit to detect the HER-2
/neu gene in breast cancer patients for use in identifying women with metastatic breast cancer who could benefit from Herceptin therapy.
com adds HER-2
Positive Breast Cancer Market in the US 2015-2019 and Global HER-2
Positive Breast Cancer Market 2015-2019 industry research reports in its store.
Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), today announced preliminary data from two ongoing studies, one evaluating neratinib (HKI-272) in combination with trastuzumab (Herceptin(R), Roche) in HER-2
positive (ErbB-2 positive) breast cancer, and a separate study investigating neratinib safety and efficacy when given with paclitaxel (Taxol(R), Bristol-Myers Squibb) in patients with HER-2
dependent solid tumors.
Both studies were made up of women whose disease is fueled by the HER-2
protein and whose tumors had continued to grow even after initial treatment with Herceptin, also known as trastuzumab.
gene encodes p185, a 185-kDa transmembrane tyrosine kinase growth factor receptor belonging to the epidermal growth factor receptor family.
Amplification was considered to be present when more than 4 green fluorescence signals were identified in each nucleus and amplified tumors had a minimum of 20 nuclei with more than 4 copies of the HER-2
Downers Grove, IL) says the data supports the notion that FISH is the most accurate means of assessing HER-2
status in breast cancer patients.
0 million in grants from the DOD in the development of its live Listeria vaccines directed against HER-2
for breast cancer and HMW-MAA, an antiangiogenic vaccine.