Gschwendtner et al., "Genome-wide association study identifies a variant in HDAC9
associated with large vessel ischemic stroke," Nature genetics, vol.
HDACs can be divided into four distinct families, of particular interest are class I (HDAC1, HDAC2, HDAC5, and HDAC8) and class II (HDAC5, HDAC6, HDAC7, HDAC9
, and HDAC10) HDACs .
In accordance with their structural diversity, HDACs are divided into four subtypes: Class I (HDAC1, HDAC2, HDAC3, and HDAC8), Class II consisting of IIa (HDAC4, HDAC5, HDAC7, and HDAC9
) and IIb (HDAC6 and HDAC10), Class III (a family of sirtuins), and Class IV (HDAC11) .
In the replication analysis stage, we focused on the SNPs rs1432910 and rs2278391 (SLIT3 gene), rs6904364 (RMND1 gene), rs17081341 (CCDC170 gene), rs849172 (COA1 gene), rs11764843 (HDAC9
gene), and rs17413103 (SHFM1 gene), based on the following two main criteria: (1) these SNPs reached suggestive level of significance in the discovery analysis (P values <5 x [10.sup.-5]) and (2) based on bioinformatics search criteria, these SNPs had a reported function in bone metabolism.
examined the change of HDACs 1-11 induced by ischemia and reperfusion; the results suggested that only HDAC4/5 mRNA levels were significantly decreased while HDAC9
was prominently increased in ischemic hemisphere .
Studies involving profiling of key epigenetic chromatin modulators such as HMT, HDM, HDAC, and DNMT in meditators and controls showed that the meditators displayed rapid peripheral changes in their expression of HDAC2, HDAC3, and HDAC9
along with global histone modifications (H4Ac, H3K4me3) .
The primer ser for each gene was followed: histone deacetylase 9 (HDAC9
) forward, 5'-GCAAGAGGAGACAGAGACCG-3'; HDAC9
reverse, 5' - ACTTG G C ACTTCAC AAG G CT- 3'; minichromosome maintenance deficient 3 associated protein (MCM3AP) forward, 5'-CGCTTCCTCTGGTGGTTCTT-3'; MCM3AP reverse, 5'CTGCACTGCTTGCAAAACCT-3'; GAPDH forward, 5'-TCACCCACACTGTGCCCATCTATGA-3'; GAPDH reverse, 5'-GAGGAAGAGGATGCGGCAGTGG-3'.
21 March 2014 - A study, published today in Journal of Biomedical Science, has discovered that single nucleotide polymorphism (SNP) rs10248565 at HDAC9
in chromosome 7p21.1 is a potential new genomic aberration biomarker of lung adenocarcinoma in non-smoking women.
HDAC class II consists of six types of enzymes, namely, HDAC4, HDAC5, HDAC6, HDAC7, HDAC9
, and HDAC10.
(27) Bircok kromozomun anomalileriyle birlikte bildirilen bu anomaliyle iliskili genler arasinda PITX2, FOXE3, CYP1B115 ve digenik kalitimla hastaliga neden olan HDAC9
(7p21.1) ve TGF02 (lq4l) vardir.
Two of the new loci are in or near histone deacetylase genes HDAC4 and HDAC9
. Histone deacetylases regulate expression of other genes by modifying histones, which are proteins responsible for DNA packaging.