HDAC7

A gene on chromosome 12q13.1 that encodes histone deacetylase 7, which is responsible for deacetylating lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation tags epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

References in periodicals archive ?

As shown in Figure 3, we found that the expression of histone acetyltransferase CREBBP in LADA patients was downregulated compared to healthy controls (Figure 3(a), the absolute of fold change > 2 was considered significant), and the expression of histone deacetylases HDAC1 and HDAC7 was upregulated (Figure 3(b)).

The results showed that the expression of acetyltransferase CREBBP in LADA patients was downregulated and the expression of histone deacetylase HDAC1 and HDAC7 was upregulated.

Reduced histone H3 acetylation in [CD4.sup.+] T lymphocytes: potential mechanism of latent autoimmune diabetes in adults

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.

Epigenetic targets for reversing immune defects caused by alcohol exposure

His research is focused on the functions of immune T regulatory (Treg) cells and related roles of Class II HDACs, including HDAC6, HDAC7 and HDAC9.

Acetylon Pharmaceuticals Adds HDAC Biology, Inflammation and Neurodegeneration Experts to its Scientific Advisory Board