HDAC7

HDAC7

A gene on chromosome 12q13.1 that encodes histone deacetylase 7, which is responsible for deacetylating lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation tags epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
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The selected receptors used for the docking studies are carbonic anhydrase II (CA-II), cathepsins B (Cat B) [24], two different DNAs (DNA-1 [25] and DNA-2), DNA gyrase (Gyrase) [26], histone deacetylase7 (HDAC7) [27], histone protein in the nucleosome core particle (HIS) [28], BRAF kinase (Kinase) [29], recombinant human albumin (rHA) [30], ribonucleotide reductase (RNR) [31], topoisomerase II (Top II) [32], thioredoxin reductase (TrxR) [33], and thymidylate synthase (TS) [34].
Ligands 11 and 15 have similar binding orientation in CA-II, Cat B, and HDAC7 based on the results obtained from the binding site interactions.
The Anticancer Activities of Some Nitrogen Donor Ligands Containing bis-Pyrazole, Bipyridine, and Phenanthroline Moiety Using Docking Methods
HDACs can be divided into four distinct families, of particular interest are class I (HDAC1, HDAC2, HDAC5, and HDAC8) and class II (HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10) HDACs [26].
Global knockdown of HDAC3 [33] HDAC1 [34] and HDAC7 [34] results in fetal lethality; however, mice lacking HDAC6 develop normally [35].
Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells
In accordance with their structural diversity, HDACs are divided into four subtypes: Class I (HDAC1, HDAC2, HDAC3, and HDAC8), Class II consisting of IIa (HDAC4, HDAC5, HDAC7, and HDAC9) and IIb (HDAC6 and HDAC10), Class III (a family of sirtuins), and Class IV (HDAC11) [4].
Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia
SIRT1 gene expression is significantly increased, while CBP, p300, HDAC2, HDAC7, SUV39H2, and EZH2 gene expression is significantly decreased in [CD4.sup.+] T cells of active SLE patients.
JHDM2A expression is increased, whereas HDAC2, HDAC7, and SUV39H2 expression is decreased in SSc B cells.
The Histone Modification Code in the Pathogenesis of Autoimmune Diseases
Jin, "VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis
Primers of chromatin modifier genes were used, including the histone acetyltransferases (P300 and CREBBP) and the histone deacetylases (HDAC1, HDAC2, and HDAC7).
Reduced histone H3 acetylation in [CD4.sup.+] T lymphocytes: potential mechanism of latent autoimmune diabetes in adults
HDAC class II consists of six types of enzymes, namely, HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10.
Utilization of boron compounds for the modification of suberoyl anilide hydroxamic acid as inhibitor of histone deacetylase class II Homo sapiens
HDAC7 has been extensively studied in hypoxia and COPD models.
Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.
Epigenetic targets for reversing immune defects caused by alcohol exposure
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