HDAC7

HDAC7

A gene on chromosome 12q13.1 that encodes histone deacetylase 7, which is responsible for deacetylating lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation tags epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
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References in periodicals archive ?
The selected receptors used for the docking studies are carbonic anhydrase II (CA-II), cathepsins B (Cat B) [24], two different DNAs (DNA-1 [25] and DNA-2), DNA gyrase (Gyrase) [26], histone deacetylase7 (HDAC7) [27], histone protein in the nucleosome core particle (HIS) [28], BRAF kinase (Kinase) [29], recombinant human albumin (rHA) [30], ribonucleotide reductase (RNR) [31], topoisomerase II (Top II) [32], thioredoxin reductase (TrxR) [33], and thymidylate synthase (TS) [34].
Ligands 11 and 15 have similar binding orientation in CA-II, Cat B, and HDAC7 based on the results obtained from the binding site interactions.
HDACs can be divided into four distinct families, of particular interest are class I (HDAC1, HDAC2, HDAC5, and HDAC8) and class II (HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10) HDACs [26].
Global knockdown of HDAC3 [33] HDAC1 [34] and HDAC7 [34] results in fetal lethality; however, mice lacking HDAC6 develop normally [35].
In accordance with their structural diversity, HDACs are divided into four subtypes: Class I (HDAC1, HDAC2, HDAC3, and HDAC8), Class II consisting of IIa (HDAC4, HDAC5, HDAC7, and HDAC9) and IIb (HDAC6 and HDAC10), Class III (a family of sirtuins), and Class IV (HDAC11) [4].
SIRT1 gene expression is significantly increased, while CBP, p300, HDAC2, HDAC7, SUV39H2, and EZH2 gene expression is significantly decreased in [CD4.sup.+] T cells of active SLE patients.
JHDM2A expression is increased, whereas HDAC2, HDAC7, and SUV39H2 expression is decreased in SSc B cells.
Jin, "VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Primers of chromatin modifier genes were used, including the histone acetyltransferases (P300 and CREBBP) and the histone deacetylases (HDAC1, HDAC2, and HDAC7).
HDAC class II consists of six types of enzymes, namely, HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10.
HDAC7 has been extensively studied in hypoxia and COPD models.
Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo.