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Gene Therapy to Activate HDAC4 for Retinitis Pigmentosa - Drug Profile 74
Los pacientes fueron nuevamente evaluados despues de 3 meses de actividad fisica supervisada, y encontraron que los niveles de expresion de TSP1 y HDAC4 se revirtieron, observandose niveles de expresion similares a los presentes en sujetos con peso normal.
Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity.
Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5.
HDAC4 and SRF which were the target genes of miR-1 and miR- 133 family respectively were predicted using MiRanda and Target Scan 6.
In this proposal, we plan to define the role of HDAC4 in muscle regeneration by identifying the targets responsible for the improved regeneration observed in HDAC4 null mice.
Importantly, the team also found that the two affected proteins interacted with one another; HDAC4 binds to ESRRA and inhibits it.
16) In particular, the discovery that HD mice, engineered to be deficient in HDAC4, show a phenotypic improvement suggests that this may be a promising therapeutic approach.
We used the following plasmids for transfections: HDAC1 (plasmid 13820), HDAC3 (plasmid 13819), and HDAC4 (plasmid 13821; all from Addgene).
Our results showed that inhibition of NADPH oxidase activity ameliorated cerebral ischaemia/reperfusion (I/R) injury and among Zn(2+) -dependent HDACs, HDAC4 and HDAC5 were significantly decreased both in vivo and in vitro, which can be reversed by NADPH oxidase inhibitor apocynin.
The researchers found that HDAC4 is critically involved in regulating genes essential for communication between neurons.
Two of the new loci are in or near histone deacetylase genes HDAC4 and HDAC9.
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