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Atadja, "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family," Journal of Biological Chemistry, vol.
The HDAC family comprises 11 different enzymes, sequentially named HDAC1 through HDAC11.
Searching for a solution to this dilemma, Witt's team came across a member of the HDAC family, HDAC11, which was identified only recently.
This has not been observed in healthy cells, and hardly any specific functions of HDAC11 are known there.
It therefore seemed obvious that a specific HDAC11 inhibitor would specifically target tumour cells, where this enzyme appears to play a critical role," said Dr.
As there are no specific HDAC11 inhibitors available yet, the team took a different approach to verify their hypothesis.
The result: Cancer cells without HDAC11 were impaired in viability and more often underwent cell death (apoptosis).
The result suggests that selective blocking of HDAC11 would act exclusively on tumour cells," said Hedwig Deubzer.
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