HDAC1

HDAC1

A gene on chromosome 1p34 that encodes histone deacetylase 1, which belongs to the histone deacetylase/acuc/apha family and is a part of the histone deacetylase complex. It interacts with retinoblastoma tumour-suppressor protein and controls cell proliferation and differentiation. With metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
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In the case of the HDAC assays, there were three targets, HDAC1, HDAC3 and HDAC6, tested with 41, 2 and 3 reference chemicals, respectively.
Workflow for Defining Reference Chemicals for Assessing Performance of In Vitro Assays
Mocetinostat (MGCD0103) is an isotype of HDACI and showed in vitro activity against HDAC1 selectively and some activity against the various isoforms of HDAC (2, 3, and 11).
Histone Deacetylase Inhibitors: A Prospect in Drug Discovery/Histon Deasetilaz inhibitorleri: ilac Kesfinde Bir Aday
After cells were grown to 30-50% confluence, 80 nmol/L small interfering RNA (siRNA) specific for Hdac1 (siG1379144052, GuangZhou RiboBio.
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice
MeCP2 has also its role in anchoring a multiprotein repressory complex to the DNA which is responsible for deacetylation of histones and alterations of chromatin by recruiting deactylases HDAC1 and HDAC2 also shown in Fig.
Epigenetic Alterations and their Dietary Backgrounds
Interestingly, HDAC1 has been reported to be overexpressed in HCC; yet, HDAC6 has been found to be decreased in HCCs compared with adjacent control tissues, and this observation is associated with poor prognosis (104).
Autophagy and liver cancer
Both HAT and HDAC enzymes, such as GCN5/KAT2A and HDAC1, respectively, are subunits in multiprotein complexes (Grant et al.
Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation
Similarly, in pituitary tumourigenesis, HMGA2 displaces HDAC1 from the complex Rb/E2F1, leaving the latter in an active acetylated form [81].
Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
Hu et al., "HDAC1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells," Biological Chemistry, vol.
Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors
[70] which demonstrated that a low level of chronic oxidative stress results in the malignant transformation of human renal tubular epithelial cells, and the potential role is the aberrant expression of epigenetic regulatory genes involved in DNA methylation (DNMTs) as well as histone modifications (HDAC1, HAT1) in human renal tubular epithelial cells malignantly transformed by chronic oxidative stress.
Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis
The authors reported that HDAC1 and HDAC2 were downregulated, which are associated with an increase in H3K4me3 and H3K9Ac and which are associated with an active chromatin state [7].
Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity
Su et al., "Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons," Nature Neuroscience, vol.
Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions
Cano, "Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex," Molecular and Cellular Biology, vol.
Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk

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