HDAC


Also found in: Acronyms.

HDAC

high-dose
cytarabine.
(a chemotherapeutic agent to treat acute myelogenous leukemia.
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Hdac Technology's FinTech business is driven under the initiative of HYUNDAI PAY, aiming to provide convenient daily cryptocurrency payment services.
(17) Vorinostat hinders all classes of HDAC proteins (I, II, and IV), except class III HDAC, which is NAD+ dependent.
Celine Tiffon observes that the poorly-differentiated phenotype and cell behavior associated with changes in hypoxia-regulated gene expression, were reversed by the differentiation of pancreatic cancer cells by the HDAC inhibitor TSA.
The embryonic hearts were quickly removed and stored at −80[degrees]C for further mRNA/protein expression analysis, total HDAC activity assay, or fixed in 10% formalin solution for hematoxylin-eosin staining.
This current clinical study is the first HDAC inhibitor combined with exemestane in a pivotal trial to demonstrate progression-free survival benefit and manageable adverse effect in HR-positive ABC patients progressed after prior endocrine therapy.
[29] have designed and synthesized a bifunctional Pt(IV) prodrug, VAAP (Figure 2(1)), based on oxidized cisplatin (diaminedichlorodihydroxyplatinum and ACHP) and an HDAC inhibitor, valproic acid (VPA), for cancer chemotherapy.
Our group has developed the first PET HDAC Ila radiotracer, 6-([[sup.18]F]fluoroacetamido)-1-hexanoicanilide ([[sup.18]F]FAHA), that can be used to image whole-body HDAC IIa expression and tumor activity [20].
It was apparent that most compounds identified are histone deacetylase (HDAC) inhibitors, whose action leads to hyperacetylation of histones [39] and often increased HDP gene transcription in humans [40].
HDAC technology was founded by Chung Dae-sun, the grandson of Hyundai Founder Chung Ju-yung.
Since it was first discovered in nuclear histones [11], the enzymes that catalyze protein acetylation and deacetylation are subsequently referred to as histone acetyl-transferase (HAT) and deacetylase (HDAC).
The researchers used HDAC inhibitors, occasionally used for cancer patients, in numerous white blood cell tests among human and mice macrophages, reporting the cells responded well to the unprecedented treatment.
After 5 weeks animals were sacrificed, tumor sizes were measured, and tumors were processed for evaluation of HDAC expression levels by real time qPCR.