HDAC6

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HDAC6

A gene on chromosome Xp11.23 that encodes histone deacetylase 6; it belongs to class II of the histone deacetylase/acuc/apha family, which has histone deacetylase activity and represses transcription. HDAC6 plays a key role in degrading misfolded proteins too abundant for chaperone refolding and the ubiquitin-proteasome system by transporting the miscreants to aggresomes, which clear the misfoldizens by autophagy.
References in periodicals archive ?
The expression of some [alpha]-defensins and [beta]-defensins is regulated in a microbial-independent manner, through the expression of proinflammatory cytokines including IL-1[beta] (HD5, HD6, or HBD1).
have demonstrated that ileal CD is associated with a marked decrease in HD5 and HD6 expression in Paneth cells, compared to controls [59].
Also affordable was HD1, which includes Huddersfield town centre; HD4 (Newsome), HD7 (Colne Valley), HD6 (Brighouse), HD5 (Dalton and Kirkheaton) and HD3 (Lindley, Salendine Nook and Outlane).
From Noon, they will be gathering at Woodhouse Playing Fields (HD6 3UH).
Visit Artisan Fireplaces at Phoenix Street, Brighouse, HD6 1PD.
Anyone interested should go to St John's Community Hall, off Gooder Lane, Rastrick, Brighouse, HD6 1HN on Wednesday, July 4 at 7.30pm.
Prego Italian Cafe Bar and Restaurant Huddersfield Road, Brighouse, HD6 1JZ xxx Phone: 01484 715 566 Website: www.waterfronthotelandvenue.co.uk/Prego-Restaurant Opening hours: Monday to Friday 5pm-10pm; Saturday 12pm-10pm; Sunday 12-8pm.
A number of streets in the town are closed during the weekend and while some car parking in the centre is still available, visitors are advised to use the designated event parking on Armytage Road (HD6 1PT), off Junction 25 of the M62.
Bellini's 25 Phoenix St, Brighouse HD6 1PD Phone: 01484 400114 Website: http://www.bellinisitalian.co.uk/ Opening hours: Closed Monday Tuesday to Thursday 5pm-9pm Friday to Saturday 12pm-11pm Sunday 4pm-8pm Children: Yes The bill: PS51.10
Meze5 Bethel Street Brighouse West Yorkshire HD6 1JR Phone: 01484 722778 Website: www.mezerestaurant.co.uk Opening hours: Sunday to Thursday 12pm-8.30pm (last food order); Friday and Saturday 12pm-9.30pm (last food order).
47 Grains 47 Briggate, Brighouse, Huddersfield, HD6 1EB Phone: 01484 937977 Website: www.47grains.co.uk Opening hours: Wednesday-Thursday 5pm to 9pm.