HTT

(redirected from HD protein)

HTT

A gene on chromosome 4p16.3 that encodes huntingtin, a protein thought to play a role in microtubule-mediated transport or vesicle function.
 
Molecular
Pathology HTT mutations are linked to Huntington’s disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The EMA's decision to grant PRIME designation was primarily based on data from an exploratory Phase I/IIa trial that demonstrated a mean 40% (up to 60%) reduction of the specific HD protein in the cerebrospinal fluid (CSF) of adult patients treated with RG6042 for three months at the highest doses.
first identified an HD protein ATHB7 from Arabidopsis thaliana, which was highly induced by salt, osmotic stress, and ABA treatment [9].
The study reported a significant reduction in the disease-causing HD protein in mice and a significant improvement in the motor functions and neurological abnormalities associated with the disease.
Results also demonstrated that levels of toxic HD protein in siRNA treated mice were reduced to 40 percent of normal levels.
It is very exciting that a partial reduction in the HD protein is sufficient to produce a very beneficial effect in the animal.
Further, the antib odies verified the prediction that mussel Lim-1 antigens, like Lim-1 HD proteins in general, can be localized in the nucleus.