Also found in: Dictionary, Acronyms, Encyclopedia.


Abbreviation for homocysteine.
Farlex Partner Medical Dictionary © Farlex 2012




HSCH2CH2CH(NH2)COOH; an amino acid produced by the catabolism of methionine. With serine, it forms a complex that eventually produces cysteine and homoserine. There is evidence that a high level of homocysteine in the blood may be associated with an increased risk of developing atherosclerosis. Although blood homocysteine levels may be lowered by eating foods rich in folic acid, e.g., green leafy vegetables and fruits, and by vitamin pills containing folic acid and vitamin B6 or B12, research has failed to show that any of these causes a significant reduction in cardiovascular disease.
Medical Dictionary, © 2009 Farlex and Partners
Mentioned in ?
References in periodicals archive ?
Table-III: Mean +- SD of serum homocysteine (Hcy) of cases and controls in 2nd and 3rd trimester.
Mean + SD was calculated for numerical variables like age, BMI, serum Hcy level, HbA1C levels systolic blood pressure and duration of diabetes.
To the best of our knowledge, this case of CBS deficiency for Hcy metabolism heralded by CVST represents a very rare reported case with c.154 T>C (p.C52R) and c.457G>A (p.G153R) mutations.
From a biochemical viewpoint, there is evidence that the rise in blood Hcy levels observed in PSD patients is ascribed to methylation failure of Hcy to methionine due to a supply shortage of methyl groups from methyl folate or lack of vitamin B12 cofactor for this methylation reaction.6 Methionine is the precursor of S-adenosylmethionine (SAMe), the methyl donor in a host of methylation reactions in the central nervous system involving monoamines and various neurotransmitters.
Hcy was correlated with serum creatinine (P=0.002), GFR (P=0.003), and dialysis time (P=0.02).
SDS-soluble and SDS-insoluble pellets were transferred to 1 ml Wheaton Gold Band ampoules and hydrolyzed with 6N HCl and 50 mM DTT (110 [micro]l, 120[degrees]C, 1 h) to liberate Hcy. The hydrolysates were lyophilized on Labconco CentriVap (40 min, 70[degrees]C), dissolved in 10 [micro]l water, purified by two-dimensional TLC, and analyzed by HPLC.
Three statistical models were used as unadjusted, adjusted for age and sex, and adjusted for age, sex, Hcy, BMI, duration of diabetes, hypertension, smoking, total cholesterol, and TG levels.
The meta-analysis showed that most COCs were associated with worsening CRP concentrations, nonsignificant changes in Hcy levels, increase in follistatin, and conflicting results regarding IL-6 concentrations.
All studies reporting serum Hcy levels in patients with ED and control population were included.
In RA patients, ADMA showed a positive correlation with Hcy levels and it is associated with insulin resistance (the homeostasis model assessment (HOMA) being a strong predictor of ADMA serum levels) [92, 93].
Serum levels of homocysteine (Hcy), eosinophil cationic peptide (ECP), 25-hydroxyvitamin D (25(OH)D), interleukin-1[beta] (IL-1[beta]), soluble [OX.sub.2] (sCD200) and clinical follow-up tests including fractional exhaled nitric oxide (FeNO), asthma control test (ACT), and pulmonary function tests were evaluated.