HCN4

A gene on chromosome 15q24.1 that encodes a member of the hyperpolarisation-activated cyclic nucleotide-gated potassium channels, which has slow activation and inactivation kinetics, and is critical in cardiac pacemaking. HCN4 may mediate responses to sour taste stimuli.

Molecular pathology
HCN4 mutations are linked to sick sinus syndrome 2—e.g., atrial fibrillation with bradyarrhythmia or familial sinus bradycardia.

Mentioned in ?

Atrial Dysrhythmias

References in periodicals archive ?

Effects of Shensong Yangxin capsule on pacemaker channels encoded by human HCN4 gene.

Effect of the Shensong Yangxin Capsule on Energy Metabolism in Angiotensin II-Induced Cardiac Hypertrophy

Expression of Hcn1 (4-fold) and Hcn4 (5-fold) were downregulated in GK compared to control SAN.

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart

Six other genes (CACNA1C, CACNB2, SCN1B, KCNQ3, SCN3B, and HCN4) have been associated with BrS, but the prevalence of variants in these genes is yet unknown (6).

A Report of Brugada Syndrome Presenting with Cardiac Arrest Triggered by Verapamil Intoxication

Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. Journal of Cellular Physiology, v.212, n.2, p.285-292, 2007.

MicroRNAs in veterinary cardiology/MicroRNAs em cardiologia veterinaria

HCN4 is the most widespread isoform in the sinoatrial node and is responsible for diastolic depolarisation [4-6].

Application and Validation of Simple Isocratic HPLC-UV-DAD Method with Dual Wavelength Detection for Ivabradine Determination and Its Application in the Study of Stress Degradation

Pan et al., "Down-regulation of miR-1/miR133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart," Journal of Biological Chemistry, vol.

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

However, THSG treatment increases the percentage of the S-phase in sorted c-kit(+) rat cardiac stem cells and promotes expressions of PCNA, VEGF, the T-box transcription factor, hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2), HCN4, the a myosin heavy chain, [beta] myosin heavy chain mRNA, stem cell antigen 1, cardiac troponin-I, GATA-4, Nkx2.5, and connexin 43 protein [22].

Biological Activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-[beta]-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

[11] Further support for the hypothesized common etiology comes from a preliminary molecular genetic study which found that hyperpolarization activated cyclic nucleotide-gated channel 4 (HCN4) is a common susceptible locus for both mood disorders and OCD, but further studies with larger sample sizes are needed to replicate this finding.

Comorbid bipolar disorder and obsessive-compulsive disorder

D'Souza A (1) et al supported in their study that training-induced bradycardia is not a consequence of changes in the activity of the autonomic nervous system but is caused by intrinsic electrophysiological changes in the sinus node so concluded Exercise training reduces resting heart rate via down regulation of the funny channel HCN4.

ECG changes in young competitive Indian athletes

Actually the heart's pacemaker changes in response to training and in particular there is a decrease in an important pacemaker protein, known as HCN4, and this is responsible for the low heart rate," she added.

Why athletes likelier to need pacemakers during old age

Viscomi et al., "Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4," Proceedings of the National Academy of Sciences of the United States of America, vol.

Isoprenaline: a potential contributor in sick sinus syndrome--insights from a mathematical model of the rabbit sinoatrial node