HCN4

HCN4

A gene on chromosome 15q24.1 that encodes a member of the hyperpolarisation-activated cyclic nucleotide-gated potassium channels, which has slow activation and inactivation kinetics, and is critical in cardiac pacemaking. HCN4 may mediate responses to sour taste stimuli.

Molecular pathology
HCN4 mutations are linked to sick sinus syndrome 2—e.g., atrial fibrillation with bradyarrhythmia or familial sinus bradycardia.
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References in periodicals archive ?
Effects of Shensong Yangxin capsule on pacemaker channels encoded by human HCN4 gene.
Expression of Hcn1 (4-fold) and Hcn4 (5-fold) were downregulated in GK compared to control SAN.
Six other genes (CACNA1C, CACNB2, SCN1B, KCNQ3, SCN3B, and HCN4) have been associated with BrS, but the prevalence of variants in these genes is yet unknown (6).
Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. Journal of Cellular Physiology, v.212, n.2, p.285-292, 2007.
Pan et al., "Down-regulation of miR-1/miR133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart," Journal of Biological Chemistry, vol.
However, THSG treatment increases the percentage of the S-phase in sorted c-kit(+) rat cardiac stem cells and promotes expressions of PCNA, VEGF, the T-box transcription factor, hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2), HCN4, the a myosin heavy chain, [beta] myosin heavy chain mRNA, stem cell antigen 1, cardiac troponin-I, GATA-4, Nkx2.5, and connexin 43 protein [22].
[11] Further support for the hypothesized common etiology comes from a preliminary molecular genetic study which found that hyperpolarization activated cyclic nucleotide-gated channel 4 (HCN4) is a common susceptible locus for both mood disorders and OCD, but further studies with larger sample sizes are needed to replicate this finding.
D'Souza A (1) et al supported in their study that training-induced bradycardia is not a consequence of changes in the activity of the autonomic nervous system but is caused by intrinsic electrophysiological changes in the sinus node so concluded Exercise training reduces resting heart rate via down regulation of the funny channel HCN4.
Actually the heart's pacemaker changes in response to training and in particular there is a decrease in an important pacemaker protein, known as HCN4, and this is responsible for the low heart rate," she added.
Viscomi et al., "Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4," Proceedings of the National Academy of Sciences of the United States of America, vol.