HCN1A gene on chromosome 11q12 that encodes a protein which removes 5' overhanging flaps in DNA repair, and processes the 5' ends of Okazaki
fragments in lagging-strand DNA synthesis. Direct physical interaction between FEN1 and AP endonuclease 1 during long-patch base excision repair provides co-ordinated loading of the proteins onto the substrate, passing substrate from one enzyme to another. FEN1 belongs to the XPG/RAD2 endonuclease family and is one of 10 proteins essential for cell-free DNA replication.
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