CD44

(redirected from HCELL)

CD44

a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.

CD44

A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive ?
Sackstein, "The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing," The Journal of Investigative Dermatology, vol.
Increased expression of CD44 known as hematopoietic cell E-/L-selectin ligand (HCELL) on colon carcinoma resulted in an enhanced adherence to activated endothelium [113].
Sackstein, "HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells," Journal of Biological Chemistry, vol.
[128] applied this technique to modify the cell surface of MSCs, to form HCELL, an E-selectin and L-selectin binding ligand.
HSPCs express at least 1 P-selectin (sP) ligand, sP glycoprotein ligand-1 (PSGL-1/CD162), and another selectin ligand, HCELL (15, 16) Primitive [CD34.sup.+] HSPCs have been demonstrated to exhibit stronger rolling adhesion on selectins than mature [CD34.sup.-] MNCs (14, 17).
This process resulted in the development of the variable CELL, which is a combination of the two questions relating to cell phone usage (LCELL and HCELL; r = 0.73).
Differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1.
Moreover, PAWLAK and colleagues (2004), when studying the effect of diets with high and low glycemic responses on glycemic and lipidic metabolism in rats, observed that the pancreatic islets of the animals consuming a high glycemic response diet showed a significant increase in the proportion of abnormal hcells, with severe disruption of islet-cell architecture and islet fibrosis, which could result in an increase in the organ's weight.