FZR1

(redirected from HCDH)
Also found in: Acronyms.

FZR1

A gene on chromosome 19p13.3 that encodes a key regulator of ligase activity of the anaphase-promoting complex/cyclosome (APC/C), conferring substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis (in place of CDC20) and activates the APC/C during anaphase and telophase. The APC/C degrades the substrate to ensure that cell cycle upregulators do not accumulate prematurely; at the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. FZR1 is highly expressed in the heart, liver, spleen, and in some cancer cell lines.
References in periodicals archive ?
Such a vision is made possible by the Incarnation of God as man in Christ, which "opened all potentialities of the knowledge of the kingdom of heaven in and through matter" (HCDH 74).
High concentrations of acetyl-CoA in the liver may have inhibited fatty acid [beta]-oxidation, so that expression of HCDH was decreased.
HCDH NU, Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, Doc.
Les lacunes constat[euro]u[c]es dans les rapports sur les droits de l'homme sont dues [euro]u "la capacit[euro]u[c] de surveillance limit[euro]u[c]e" du Haut commissariat des Nations Unies pour les droits de lae1/4aohomme (HCDH) dans les territoires occup[euro]u[c]s, explique Guterres.
Le Haut-commissariat des Nations unies aux droits de l'homme (HCDH) s'est dit [beaucoup moins que] alarme [beaucoup plus grand que] par la [beaucoup moins que] forte hausse [beaucoup plus grand que] du nombre de victimes civiles au Yemen, notamment dans le gouvernorat de Ta'izz.
Le secretariat du Conseil des droits de l'Homme est assure par le Haut-Commissariat des Nations unies aux droits de l'Homme (HCDH).
Le president Abdelaziz a rappele que les conclusions de la mission du HCDH au Sahara occidental en 2006 avaient confirme que les violations des droits de l'homme dans ce territoire etaient le resultat de [beaucoup moins que]la non-application de la legalite internationale, du droit international, des resolutions onusiennes et du droit du peuple sahraoui a l'autodetermination[beaucoup plus grand que].