MCM3

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MCM3

A gene on chromosome 6p12 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA-replication-related proteins. The complex is required for the entry in S phase and for cell division. MCM3 interacts directly with MCM5/CDC46; it is acetylated by MCM3AP, a chromatin-associated acetyltransferase, which inhibits the initiation of DNA replication and cell cycle progression.
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It belongs to the family Flaviviridae and the genus Hepacivirus and its genome contains a linear, positive-strand ribonucleic acid (RNA) molecule of ~9,500 nucleotides.1 HCV is the leading cause of chronic liver diseases and hepatocellular carcinoma (HCC).2 HCC is amongst the top three cancer causes of death worldwide with hepatitis B and C viruses (HBV/HCV) as the main aetiological agents.3 Egypt has the highest HCV prevalence worldwide and as many as 20% of infected individuals will develop liver cirrhosis, on average 20-30 years after infection which finally develops to liver cancer.4 Moreover, Egypt is one of the global hot spots of HCC5 as it is the second most common malignancy in Egypt.