CCL16

(redirected from HCC-4)

CCL16

A gene on chromosome 17q11.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL16 is chemotactic for lymphocytes and monocytes, but not neutrophils. It is a potent myelosuppressor, suppressing the proliferation of myeloid stem cells. CCL16 expression is upregulated by IL-10.
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The annual incidence of HCC was 0.06% in the group designated as low risk, 0.5% in the group designated as medium risk, and 2.6% in the group designated as high risk, indicating that this "HCC-4 risk score" was indeed highly predictive, Dr.
Major finding: The annual incidence of HCC was 0.06% in the group designated as low risk, 0.5% in the group designated as medium risk, and 2.6% in the group designated as high risk, indicating that the HCC-4 risk score was highly predictive of actual outcomes.