HCAR2 | definition of HCAR2 by Medical dictionary
HCAR2 A gene on chromosome 12q24.31 that encodes a G protein-coupled receptor. HCAR2 is a high-affinity receptor for nicotinic acid/niacin and for beta-hydroxybutyrate; it increases adiponectin secretion and reduces lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase.
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References in periodicals archive
Interestingly, mammalian genomes (humans, mice, and rats) also encode three nicotinic acid receptors in the A11 subfamily of rhodopsin-like GPCRs (genes HCAR1, HCAR2
, and HCAR3).
Because the CD value of dimethyl fumarate is over 10 [micro]M, Nrf2-independent modes of action also seem to be involved in its efficacy, including the activation of hydroxycarboxylic acid receptor 2 (HCAR2
) and immunomodulatory properties.