KAT7

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KAT7

A gene on chromosome 17q21.32 that encodes a component of the HBO1 complex which is responsible for the bulk of histone H4 acetylation. KAT7 specifically represses AR-mediated transcription; it may regulate DNA replication by chromatin acetylation and act as a coactivator of TP53-dependent transcription.
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The MYST family comprises five enzymes: MOZ, Tip60, MOF, MORF, and HBO1. This family is characterized by the presence of a highly conserved 370-residue MYST domain and other domains relevant for the recognition of other proteins [28, 29].
Hbo1, a histone acetyltransferase binding to origin recognition complex (ORC1), (17) regulates histone acetylation, (18-20) replicational licensing, (21,22) origin activation, (23) adipogenesis, (24) pluripotency and self-renewal of embryonic stem cells, (25) and chromatin assembly of centromeres.
Here we investigated molecular mechanism of the promoted ubiquitination of ER[alpha] by Hbo1. The ligand-binding domain (LBD) of ER[alpha] was ubiquitinated by Hbo1.
The recombinant KAT7 (Hbo1 purified from Sf9 cells), MurFl, GST-tagged p53, and ubiquitin proteins were purchased from Active Motif (Carlsbad, CA, USA), R&D systems (Minneapolis, MN, USA), EMD Millipore (Temecula, CA, USA) and UBPBio (Aurora, CO, USA), respectively.
The His-tagged full-length human Hbo1 (amino acids: 1-611) protein was purified on Heparin Sepharose (GE Healthcare, Little Chalfont, UK), whereas His-Hbo1 (amino acids: 225-611) and His-Hbo1 (amino acids: 311-611) proteins (28) were purified on Ni-NTA Agarose (Qiagen, Hilden, Germany).
(34) siRNAs for Hbo1 targeted nucleotide 92 of the coding sequences of Hbo1.
Hbo1. To map sites of ER[alpha] ubiquitination promoted by Hbo1, deletion mutants of ER[alpha] were constructed (Fig.
In response to DDR, increased IncRNA-JADE interacts with breast cancer type 1 susceptibility protein (Brca1) and induces expression of Jade1, a major component of human acetylase binding to ORC 1 (HBO1) histone acetylation complex.
Three circular (diameter, 1.6 m: height, 0.6 m) 700-L mesocosms at HBO1 were supplied with ambient seawater from the IRL at a flow rate of 10 L/min, and were aerated to maintain high dissolved oxygen levels (Table 1) and to keep seston in suspension.
Bewkes oversees a domestic operation that includes four HBO channels - HBO1, HBO2, HBO3 and HBO Family - and three channels of its sister net Cinemax.
Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor [alpha] Masayoshi IIZUKA, Takao SUSA, Mimi TAMAMORI-ADACHI, Hiroko OKINAGA and Tomoki OKAZAKI Communicated by Takao SEKIYA, M.J.A.