SCN5A

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Also found in: Acronyms.

SCN5A

A gene on chromosome 3p21 that encodes an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel alpha subunit, which is expressed primarily in cardiac myocytes and is responsible beginning the action potential as seen on an ECG/EKG.
 
Molecular pathology
SCN5A mutations are long QT syndrome type 3.
References in periodicals archive ?
TABLE 6 Summary of Average Error Calculations - Web Schedules (n = 560) Error Type Model AER (%) APE (%) Binomial 21.00 41.50 BBD 2.50 8.63 CBD 2.43 9.66 MSAD 3.51 18.80 DMD 6.67 24.10 HBBD 2.23 9.78 The error in each exposure level is simply defined as the absolute difference between the observed and the estimate frequencies.
The best-performing model for the error in reach criterion was HBBD with an AER of 2.23 percent.
Of the six models studied, the Hofmans' Beta Binomial Distribution (HBBD), Conditional Beta Distribution (CBD), and the Beta Binomial Distribution (BBD) have the lowest APE in distribution.