PYCARD

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PYCARD

A gene on chromosome 16p11.2 that encodes an adaptor protein  composed of two protein–protein interaction domains: an N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD), both of which belong to the six-helix bundle death domain-fold superfamily. This superfamily mediates assembly of large signalling complexes in the inflammatory and apoptotic-signalling pathways by activating caspase. In normal cells, PYCARD localises to the cytoplasm, but in cells undergoing apoptosis it forms ball-like aggregates near the nucleus.
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References in periodicals archive ?
In this study, we hypothesized that the role of hASCs in inflammatory diseases may be influenced by miRNA expression patterns.
This review included previous panel interviews of business owners, including the 2012 HASC study; opinionated articles; case studies; and GAO reports.
This panel hashes out the final details of the National Defense Authorization Act (NDAA), and its 48 members--34 of them from the HASC and SASC--got, in all, no less than $20.6 million in contributions from defense contractors and their employees between 2003 to 2014, four times as much as members of the Armed Services committees who were not appointed as conferees.
(50.) Colin Clark, "HASC Mulls Nunn-McCurdys for Operations & Support Costs," Breaking Defense, February 3, 2016, http://breakingdefense.com/2016/02/hasc-mulls-nunn-mccurdys-for-operations-support-costs/.
The four relevant congressional committees--the House/Senate Armed Services Committees (HASC and SASC) and the House/Senate Appropriations Committees (HAC and SAC)--have the authority to eliminate, reduce, restrict, or defund any program deemed parochial and not in the best interest of the nation.
He has partnered with a number of social service agencies which serve individuals with developmental disabilities including AHRC of Nassau and Suffolk Counties, ARC of Rockland County, The HASC Center, Clearbrook, and Misericordia Heart of Mercy--to not only create training facilities for individuals with developmental and intellectual disabilities, but also fully operational processing plants which hire people with disabilities.
Vaz MP, Mr Hall said: "I believe that BBC journalists have In a letter to Home Aairs Select Committee (HASC) chairman Keith Vaz MP, Mr Hall said: "I believe that BBjournalists have acted appropriately in pursuing this story.
Force head David Crompton and Lord Tony Hall have been warned to stand ready to give evidence to the Home Affairs Select Committee (HASC) after Parliament returns from recess.
The large volume of discarded adipose and clinical connections allow us the opportunity to study the impact of spheroid culturing techniques on hASC viability, differentiation, and overall
6523 12/17/10 HASC #650 Committee (y341-n48) Print ll1-5 12/2010 (qq) 2012 H.R.
The new probe comes after a scathing report by the Commons Home Affairs Select Committee (HASC) accused the trio of "obstructing the truth" when they initially appeared before the committee.
Sgt Jones and Det Sgt Hinton have also been called to appear before the HASC for a second time on Tuesday, after being accused of giving "misleading" answers to MPs on October 23.