APEX1

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APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.
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Zhang, "Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1," Molecular and Cellular Biology, vol.
The number of haplotypes in different generations for the Langshan conservation population Generation Haplotype 0 5 10 15 16 17 Hap1 2 1 -- -- -- -- Hap2 23 22 31 30 28 30 Hap3 1 3 -- -- -- -- Hap4 1 1 1 1 3 2 Hap5 -- -- 1 4 4 1 Table 4.
Data from mixed populations were separated with respect to the nearest likely source population; for example, WF data for Hap1 (indicating the SD clade and the QD source population) and Hap 2 (indicating the LN clade and the DL source population) are shown in panel A and B, respectively.
Hickson, "Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding," Molecular and Cellular Biology, vol.
SLA-DRA gene haplotype and its association with piglet diarrhea Name Haplotypes Frequency (%) Diarrhea piglets Number Frequency (%) Hap1 ATACTAAAGG 8.63 4 4.17 Hap2 ATACTGAAGG 4.27 7 7.29 Hap3 ATCCTGAAGG 2.60 1 1.04 Hap4 GTACTAAAGG 8.89 3 3.13 Hap5 GTACTGAAGG 4.13 8 8.33 Hap6 GTACCAAGGA 2.08 4 4.17 Hap7 GTCCTAAAGG 9.67 4 4.17 Hap8 GTCCTGAAGG 8.13 13 13.54 Hap9 GTCCCAAGGA 2.64 0 0 Hap10 GTCTTAAAGG 6.25 10 10.42 Hap11 GTCTCAAGGA 3.28 3 3.12 Hap12 GTCTCGGAGG 2.64 3 3.12 Hap13 GCACTGAAGG 6.64 5 5.21 Hap14 GCCCTAAAGG 6.54 8 8.33 Others 23.61 23 23.96 SLA, swine leukocyte antigen.
Hap1, Hap2, and Hap3 were found in the populations from Shandong (97.7%), Beijing (100.0%), Yunnan (100.0%), and California (80.0%).
Haplotypes and their frequencies of the five SNPs Haplotype SNPs Frequency Hap1 AGCTG 0.5026 Hap2 CCTCC 0.4634 Hap3 AGCCG 0.0196 Hap4 CGCCG 0.0092 Hap5 CGTTG 0.0039 Hap6 CCTCG 0.0013 Table 6.
Moreover, Hap1 and Hap2 (present in seven and nine breeds, respectively) are the numerical dominating haplotypes.