AKAP5

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AKAP5

A gene on chromosome 14q21-q24 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunit of protein kinase A (PKA), confining the enzyme to discrete locations within the cell. AKAP5 binds to the RII-beta regulatory subunit of PKA, as well as to protein kinase C and the phosphatase calcineurin. It is primarily expressed in the cerebral cortex, may anchor the PKA protein at postsynaptic densities (PSD) and be involved in regulating postsynaptic events; it is also expressed in T cells and may inhibit IL-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
References in periodicals archive ?
One milliliter cultures of WT, CF9, CV13, CV14, H19, H20, and H21 were grown aerobically overnight and diluted to [A.
The protective effects of the violacein pigment against UV-C irradiation in chromobacterium violaceum
67%) is obtained when the members of the main corpus are the individual papers in H-IV (H8, H28, H68, H21, H67, H85) and M-III (M10, M14, M37, M41, M42, M43, M47, M48, M58), but it rises to 62.
Testing delta on the disputed federalist papers
Only the H21 and H24 hypotheses' moderating effects are significant, which means that communication dilutes their initial effects in a statistically significant fashion.
The moderator effect of communication in marketing channels of distribution; the case of car's industry in Canada
The regression formula used to test H21 till H23 is
The relationship among corporate political resources, political strategies, and political benefits of firms in China: based on resource dependency theory
Finally, H20 and H21 state that after successful implementation of JIT, organizations are able to design new products with less development cost and less manufacturing cost.
An exploration of the links between just-in-time manufacturing and simultaneous new product development
Models H21 and H24 high-pressure valves have a redesigned guide pin that provides high sealability at lower cost.
High-pressure valves
They referred the matter on to the Jockey Club, who will examine Rigmarole's withdrawal under Instruction H21, 'Withdrawal of Top Weights', which may result in a veterinary examination of the horse.
RACING: Nicholls' return secures consecutive trainers' titles
Series 20 valve models H21 and H24 have a redesigned guide pin that provides high sealing ability at a lower cost.
High pressure valves
H21 and H91 are ideal substrates for both PVD and CVD coatings.
Milling insert blanks
Si su actitud es sospechosa, mas lo es el radiograma que Kalle envia al jefe del espionaje germano en Holanda, dandole instrucciones de que remita a la Oficina de Pagos de Paris la cantidad, nada desdenable, de quince mil pesetas, que se han de entregar al agente H21.
Mata Hari: evocacion extemporanea: notable y voraz traductor (ha vertido la Biblia al espanol directamente de las lenguas originales), poliglota consumado, autor de una obra propia que incluye casi todos los generos y presencia constante en los medios de comunicacion, Ernesto de la Pena nos brinda el perfil de una mujer legendaria que aun esta a la espera de su reivindicacion
Se le dio matricula H21 y durante un ano completo permanecio en Paris casi sin hacer nada.
Reabir el caso Mata Hari
After repeated interrogations, Mata Hari finally succumbed and confessed to being a spy - code name H21.
Perspective: Lifting the veil on Mata Hari's life of intrigue and pillow talk; Gabrielle Fagan examines the enigma of Mata Hari, 83 years after the femme fatale was shot as a spy
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