Acid-suppressing medications, including Proton pump inhibitors (PPI) and H2 receptor
antagonists (H2RA), are among the most commonly used medications in developed countries.
Famotidine works by blocking the histamine H2 receptor
The authors report on seven randomised controlled trials comparing H2 receptor
antagonists to proton pump inhibitors, but in fact a recent meta-analysis to be published by Alhazzani et al (2) and our own recently published work (3) both suggest the literature includes many more valid randomised controlled trials (14 and 13 respectively, including up to ten fully published trials with the remainder in abstracts, providing sufficient information for inclusion in meta-analysis).
Combination treatment as a second-generation antihistaminic in the morning and a first-generation antihistaminic in the night and combination of H1 and H2 receptor
antagonists may be tried.
No increase in fracture risk was found for H2 receptor
antagonists (cimetadine, etc.
Some people will point to their combination of superior efficacy and high safety as a justification for using them in preference to drugs such as H2 receptor
Therapy with H2 receptor
antagonists has not been consistently successful, as Manning reported failure of this approach to control a bleeding Meckel diverticulum.
Try nonprescription strength H2 receptor
blockers (Zantac or Pepcid) taken before running and up to twice a day
Cimetidine's blockage of the H2 receptor
showed no effect.
The drugs commonly used to treat peptic ulcer (histamine H2 receptor
antagonists) have also been linked hypothetically to the increase in these cancers.
There are several marketed products for the symptomatic relief of GERD, which include antacids, H2 receptor
antagonists, and PPIs.
Compared with other H2 receptor
antagonists, the Roxatidine contains higher selectivity for H2 receptors
and features a stronger effect on acid suppression.