CD59

(redirected from H19)

CD59

a glycosylphosphatidylinositol-anchored membrane protein present on many hemopoietic cells, vascular endothelium, epithelial cells, and placenta that inhibits membrane complement attack and may be involved in T-cell signal transduction; absent or defective in paroxysmal nocturnal hemoglobinuria.
Farlex Partner Medical Dictionary © Farlex 2012

CD59

A 65-kD membrane, glycosyl-phosphatidylinositol-anchored complement-neutralising protein encoded by CD59 on chromosome 11p13, which inhibits the complement membrane attack complex, binding to C8 and C9 during assembly of the complex.

Normal expression
Most leukocytes and red cells.

Abnormal expression
May be absent in some forms of paroxysmal nocturnal haemoglobinuria.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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They analysed two differentially methylated regions (DMRs): the IGF2 DMR and the DMR upstream of the neighboring H19 gene (H19 DMR).
Can father's obesity effect offspring's health?
Some well-studied lncRNAs, including H19, NBR2, ARF, HOTAIR (HOX transcript antisense RNA), and NEAT1, have been shown to act as oncogenes or tumor suppressor genes, which are also correlated with drug resistance (12-16).
Downregulation of lncRNA CCDC26 contributes to imatinib resistance in human gastrointestinal stromal tumors through IGF-1R upregulation
Among females, the strongest association in NHBCS was observed at the imprinted maternally expressed transcript, H19 ([[beta].sub.1] = -0.909; 95% CI: -1.353, -0.465; p = 0.000083), which did not yield an association in RICHS but did yield somewhat attenuated associations in both male-specific strata (NHBCS: [[beta].sub.1] = -0.372; 95% CI: -0.778, 0.035; p = 0.073; RICHS: [[beta].sub.1] = -0.400; 95% CI: -0.743, -0.056; p = 0.023).
Placental Expression of Imprinted Genes, Overall and in Sex-Specific Patterns, Associated with Placental Cadmium Concentrations and Birth Size
The tweet said: "Routes 114 183 223 H9 H10 H18 and H19 are diverted with possible delays due to a burst water main on Kenton Road."
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A study analyzed the overexpression of H19 in human trophoblasts and detected the cell proliferation with CCK-8 technology.
Advances of Long Noncoding RNAs-mediated Regulation in Reproduction
H19. LncRNA H19, transcribed only from the maternally inherited (imprinted) allele, is involved in the postnatal development and tumorigenesis [87, 88].
Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials
H19. H19 (imprinted maternally expressed transcript) is one of the highly upregulated genes during the induction of primitive stem cells with osteogenic induction medium.
An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells
Zhang, "Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer," Scientific Reports, vol.
Prognostic Value of Long Noncoding RNAs in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis
Measured Notation Nominal Nominal diameter yield Yield Tensile (mm) strength strength strength (MPa) (MPa) (MPa) N13 12.7 400.0 510.9 624.8 N19 19.1 400.0 549.5 617.0 N25 25.4 400.0 539.0 689.6 H13 12.7 600.0 715.8 740.3 H19 19.1 600.0 686.9 778.2 H25 25.4 600.0 668.6 822.6 Table 4: Comparison on the maximum dowel force.
Dowel Behavior of Rebars in Small Concrete Block for Sliding Slab Track on Railway Bridges
The H19 gene is a conserved and maternally expressed gene located on human chromosome 11p15 that plays key roles in embryonal development and growth control [14, 15].
The lncRNA H19 Promotes Cell Proliferation by Competitively Binding to miR-200a and Derepressing [beta]-Catenin Expression in Colorectal Cancer
Other Newcastle scores: 94 Mark Peel (h27), 89 Jonny McDermott (h19), 88 David Wakenshaw (h15).
Wakey, Wakey, rise and shine! GOLF

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